Protein Alignment alpha-Est2 and Ache

DIOPT Version :9

• Sequence 1: NP_001262345.1
• Gene: alpha-Est2 / 40908
• FlyBaseID: FBgn0015570
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: XP_036020624.1
• Gene: Ache / 11423
• MGIID: 87876
• Length: 616
• Species: Mus musculus
• Alignment Length: 609
• Identity: 178/609 - (29%)
• Similarity: 287/609 - (47%)
• Gaps: 119/609 - (19%)

  Fly    10 LIKMGAQLVGHKVQQYRLSTGHTVILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRF 74
            |:..||:..|.:..|        :::..:.||:||::.|.  ...|..||.|||:|:||||..||
Mouse    24 LLGGGARAEGREDPQ--------LLVRVRGGQLRGIRLKA--PGGPVSAFLGIPFAEPPVGSRRF 78

  Fly    75 RAPQPPEPWQGVLNCTTNRSKPMQR-NMLLGIVEG----------SEDCLHLNVYVKALKSEKPL 128
            ..|:|..||.|||:.||.::...|. :.|....||          |||||:|||:....:...|.
Mouse    79 MPPEPKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPASPT 143

  Fly   129 PVIVWIYGGGFQKGEASRDIYSPDYFMK-KPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQ 192
            ||::|||||||..|.||.|:|...:..: :..|.|::|||:...|||:|...: :.|||.||.||
Mouse   144 PVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSMNYRVGTFGFLALPGSR-EAPGNVGLLDQ 207

  Fly   193 VMALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPD 257
            .:||:|:.:|||.|.|||.::||.|||||:|||.:.:.:..:|.|||:|::|||        :|:
Mouse   208 RLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSG--------TPN 264

  Fly   258 NNW-----------AFRLAQNLGYK---GDEKDADVLSFLSKVCARQIAAIDQDVINLD----EV 304
            ..|           |..||:.:|..   ....|.::::     |.|...|  ||:::.:    ..
Mouse   265 GPWATVSAGEARRRATLLARLVGCPPGGAGGNDTELIA-----CLRTRPA--QDLVDHEWHVLPQ 322

  Fly   305 RSFLLFAFGPVIEPYETDHCVVPKRHKDLLS---EAWGN-----DIPVIVGGNSFEGLFSYQLVR 361
            .|...|:|.||::             .|.||   ||..|     |:.|:||....||  ||.||.
Mouse   323 ESIFRFSFVPVVD-------------GDFLSDTPEALINTGDFQDLQVLVGVVKDEG--SYFLVY 372

  Fly   362 KDPWALKNFHNILPRE---------VRETSSLEGQDLLVRRLKQLYFNNEMQESMEMFEALN--I 415
            ..|...|:..:::.|.         |.:.|.|..:.:::.....|:    .::...:.:|::  :
Mouse   373 GVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLH----PEDPTHLRDAMSAVV 433

  Fly   416 FSHRQIWHDTHRFILARQSYAPKTPTYLYRFDFDS-----PHFNQFRRLVCGDRIRGVAHADELS 475
            ..|..:.....   ||.:..|.....|.|.|:..:     |.:            .||.|..|:.
Mouse   434 GDHNVVCPVAQ---LAGRLAAQGARVYAYIFEHRASTLTWPLW------------MGVPHGYEIE 483

  Fly   476 YLFYNIIASKLDKSSMEYKTIERMVGMWTSFASSGNPNCP-ELGSAKWEAVQLKENAVEKCFNIS 539
            ::|...:...|:.::.|....:|::..||:||.:|:||.| :..|.:|...   ..|.::..:::
Mouse   484 FIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDSKSPQWPPY---TTAAQQYVSLN 545

  Fly   540 -HDLEMRDLPESDCLAVWDTFYPR 562
             ..||:|....:...|.|:.|.|:
Mouse   546 LKPLEVRRGLRAQTCAFWNRFLPK 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	164/545 (30%)
		Aes	<117..>221	CDD:223730	47/104 (45%)
Ache	XP_036020624.1	COesterase	37..563	CDD:395084	171/588 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832855
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4180
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.690