Protein Alignment alpha-Est2 and CES1

DIOPT Version :9

• Sequence 1: NP_001262345.1
• Gene: alpha-Est2 / 40908
• FlyBaseID: FBgn0015570
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_001020366.1
• Gene: CES1 / 1066
• HGNCID: 1863
• Length: 568
• Species: Homo sapiens
• Alignment Length: 596
• Identity: 176/596 - (29%)
• Similarity: 260/596 - (43%)
• Gaps: 128/596 - (21%)

  Fly    34 ILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCT-------- 90
            ::||.:|:|.|.........:|...|.|||:||||:|.|||..|||.|||..|.|.|
Human    26 VVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQ 90

  Fly    91 ------------TNRSKPMQRNMLLGIVEGSEDCLHLNVYVKA-LKSEKPLPVIVWIYGGGFQKG 142
                        |||    :.|:.|.:   |||||:||:|..| |..:..|||:|||:|||...|
Human    91 DPKAGQLLSELFTNR----KENIPLKL---SEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVG 148

  Fly   143 EASRDIYSPDY-----FMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQN 202
            .||      .|     ...:.||.|.|.|||...||.|..|.  ...||.|..|||.||||:..|
Human   149 AAS------TYDGLALAAHENVVVVTIQYRLGIWGFFSTGDE--HSRGNWGHLDQVAALRWVQDN 205

  Fly   203 IAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCAL-SEWVESPD-NNWAFRLA 265
            ||.|.|:|.::|:.|||||..||.|::.:...:.|||:||.:||.|| |..|:..| ...|.::|
Human   206 IASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGDVKPLAEQIA 270

  Fly   266 QNLGYKGDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSFLLF-----------AFGPVIEPY 319
            ...|.|      ...|.:...|.||  ..:::::.......||..           ..|.||
Human   271 ITAGCK------TTTSAVMVHCLRQ--KTEEELLETTLKMKFLSLDLQGDPRESQPLLGTVI--- 324

  Fly   320 ETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFE-------GLFSY-----QLVRKDPWAL--KNF 370
              |..::.|..::|.:|...:.:|.:||.|..|       .|.||     ||.:|...:|  |::
Human   325 --DGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIPMQLMSYPLSEGQLDQKTAMSLLWKSY 387

  Fly   371 ------HNILPREVRETSSLEGQDLLVRRLKQLYFNNEMQESMEMFEALNIFSHRQIWHDTHRFI 429
                  ..::|....:  .|.|.|..|:: |.|:              |::.:  .:.......|
Human   388 PLVCIAKELIPEATEK--YLGGTDDTVKK-KDLF--------------LDLIA--DVMFGVPSVI 433

  Fly   430 LARQSYAPKTPTYLYRFDFDSPHFNQFR--RLVCGDRIRGVAHADELSYLFYNIIAS---KLDKS 489
            :||.......|||:|.|.: .|.|:...  :.|.||      |.|||    :::..:   |...|
Human   434 VARNHRDAGAPTYMYEFQY-RPSFSSDMKPKTVIGD------HGDEL----FSVFGAPFLKEGAS 487

  Fly   490 SMEYKTIERMVGMWTSFASSGNPNCPELGSAKWEAVQLKENAVEKCFNISHDLEMRDLPESDCLA 554
            ..|.:..:.::..|.:||.:||||..  |...|.....||..::...|.....:::|..    :|
Human   488 EEEIRLSKMVMKFWANFARNGNPNGE--GLPHWPEYNQKEGYLQIGANTQAAQKLKDKE----VA 546

  Fly   555 VWDTFYPRESL 565
            .|...:.::::
Human   547 FWTNLFAKKAV 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	169/552 (31%)
		Aes	<117..>221	CDD:223730	47/109 (43%)
CES1	NP_001020366.1	COesterase	25..548	CDD:278561	175/585 (30%)
		Aes	<122..>240	CDD:223730	52/125 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142666
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.700