DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and CEL

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001798.3	Gene:	CEL / 1056	HGNCID:	1848	Length:	753	Species:	Homo sapiens

Alignment Length:	521	Identity:	155/521 - (29%)
Similarity:	235/521 - (45%)	Gaps:	73/521 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTTNRSKPMQRNM 101
            |:.|.|.|:.:|.....:....|:|||:|.|...   ...|||...|||.|.....:.:.:|..:
Human    28 TEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKA---LENPQPHPGWQGTLKAKNFKKRCLQATI 89

  Fly   102 LLGIVEGSEDCLHLNVYVKALKSE--KPLPVIVWIYGGGFQKGEASRDIYSPDYF-------MKK 157
            ......|.||||:||::|...:.:  :.|||::|||||.|..|......:..:|.       .:.
Human    90 TQDSTYGDEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRG 154

  Fly   158 PVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFNGDPNNITLMGESAGS 222
            .|:.|..|||:..|||||..|..|  |||.||:||.||:.|:.:|||.|.||||||||.|||||.
Human   155 NVIVVTFNYRVGPLGFLSTGDANL--PGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGG 217

  Fly   223 ASVHVMMTTEQTRGLFHKAIMQSGCALSEWV-ESPDNNWAFRLAQNLGYK-GDE---------KD 276
            |||.:...:...:||..:||.|||.|||.|| :.....||.::|:.:|.. ||.         .|
Human   218 ASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTD 282

  Fly   277 ADVLSFLSKVCARQIAAIDQDVINLDEVRSFLLFAFGPVIEPYETDHCVVPKRHKDLLSEAWGND 341
            ...|:...||   .:|.::..:::        ...|.|||     |...:|....:|.:.|  .|
Human   283 PRALTLAYKV---PLAGLEYPMLH--------YVGFVPVI-----DGDFIPADPINLYANA--AD 329

  Fly   342 IPVIVGGNSFEG-LFS---YQLVRKDPWAL--KNFHNILPREVRETSSLEGQDLLVRRLKQLYFN 400
            |..|.|.|:.:| :|:   ...:.|....:  ::|:.:: .|...|..|.|.........:.:..
Human   330 IDYIAGTNNMDGHIFASIDMPAINKGNKKVTEEDFYKLV-SEFTITKGLRGAKTTFDVYTESWAQ 393

  Fly   401 NEMQESMEM----FEALNIFSHRQIWHDTHRFILARQSYAPKTPTYLYRFDFDSPHFNQFRRLVC 461
            :..||:.:.    ||...:|     ...|...:...::.|....||.|.|...|       |:..
Human   394 DPSQENKKKTVVDFETDVLF-----LVPTEIALAQHRANAKSAKTYAYLFSHPS-------RMPV 446

  Fly   462 GDRIRGVAHADELSYLFYNIIASKLDKSSMEYKTIERMVGMWTSFASSGNPNCPELGSA----KW 522
            ..:..|..|||::.|:|....|:.......:....:.|:..||:||.:|:||   :|.:    .|
Human   447 YPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWTNFAKTGDPN---MGDSAVPTHW 508

  Fly   523 E 523
            |
Human   509 E 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	153/519 (29%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	49/112 (44%)
CEL	NP_001798.3	Heparin-binding	21..121		29/95 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	555..753
		17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type)	559..745
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142721
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.640