DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and Ces2a

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_598721.1	Gene:	Ces2a / 102022	MGIID:	2142491	Length:	558	Species:	Mus musculus

Alignment Length:	557	Identity:	168/557 - (30%)
Similarity:	254/557 - (45%)	Gaps:	75/557 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GWPKLIKMGAQLVGHKVQQYRLSTGHTVILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVG 70
            ||..::..|..|:   :|........:.|.:|..|||||........|....||.|||:||||||
Mouse     8 GWLCVVACGLLLL---LQHVHGQDSASPIRNTHRGQVRGSFVHVKDTKSGVHAFLGIPFAKPPVG 69

  Fly    71 DLRFRAPQPPEPWQGVLNCTT-----------NRSKPMQRNMLLGIVEGSEDCLHLNVYVKALKS 124
            .|||..|:.||||.||.:.|:           |.....:.|::|..:..|||||:||:|......
Mouse    70 LLRFAPPEDPEPWSGVRDGTSQPAMCLQPDIMNLEDAKEMNLILPPISMSEDCLYLNIYTPTHAQ 134

  Fly   125 E-KPLPVIVWIYGGGFQKGEASRDIYSPDYFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAG 188
            | ..|||:|||:|||...|.||.:..| .....:.:|.|||.|||..|||.|..|.  ...||.|
Mouse   135 EGSNLPVMVWIHGGGLVVGSASMNDVS-KLAATEEIVIVAIQYRLGVLGFFSTGDQ--HARGNWG 196

  Fly   189 LKDQVMALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWV 253
            ..|||.||||:.:|||:|.|:.:.:|:.|.|||..||...:.:..::||||.||||||.||...:
Mouse   197 YLDQVAALRWVQKNIAYFGGNRDRVTIFGVSAGGTSVSSHILSPMSKGLFHGAIMQSGVALLPDL 261

  Fly   254 ESPDNNWAFRLAQNL-GYKGDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSFLLFAFGPVIE 317
            .|..:...::...|| |.:..:.:|.:      .|.|  |...|:::.:::|...:
Mouse   262 ISDTSEVVYKTVANLSGCEATDSEALI------HCLR--AKSKQEILAINQVFKMI--------- 309

  Fly   318 PYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRKDPWALKNF-HNILPREVRET 381
            |...|...:||..::||:....:.:|.|:|.|:.|..:...:.......:||. ...||..::.|
Mouse   310 PAVVDGEFLPKHPQELLTSMDFHPVPSIIGVNTDECGWGVPMFMGLDHIIKNITRETLPAVLKNT 374

  Fly   382 SSL-----EGQDLLVRRLK---------QLYFNNEMQESMEMFEALNIFSHRQIWHDTHRFILAR 432
            ::.     |...|||....         |..|...:.:.|.:..||.: :|.|
Mouse   375 AARMMLPPECSHLLVEEYMGDTEDPETLQAQFREMLGDFMFVIPALQV-AHFQ------------ 426

  Fly   433 QSYAPKTPTYLYRFDFDSPHFNQFRRLVCGDRIRGVAHADELSYLFYNII-ASKLDKSSMEYKTI 496
               ..:.|.|.|.|.    |.:.|.:.|....:: ..|.|:::::|.:.: ...||.:..|....
Mouse   427 ---RSQAPVYFYEFQ----HLSSFIKHVRPSHVK-ADHGDDVAFVFGSYLWDMNLDLTEEEELLK 483

  Fly   497 ERMVGMWTSFASSGNPNCPELGSAKWEAVQLKENAVE 533
            ..|:..|.:||.:||||...|.|  |..:...|..::
Mouse   484 RMMMKYWANFARNGNPNSEGLPS--WPVLDHDEQYLQ 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	161/519 (31%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	45/104 (43%)
Ces2a	NP_598721.1	COesterase	30..537	CDD:278561	163/532 (31%)
Ces2a	NP_598721.1	Aes	<127..>230	CDD:223730	46/105 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832751
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640