DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and bche

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	XP_002931610.1	Gene:	bche / 100495889	XenbaseID:	XB-GENE-980117	Length:	602	Species:	Xenopus tropicalis

Alignment Length:	585	Identity:	166/585 - (28%)
Similarity:	257/585 - (43%)	Gaps:	108/585 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 GHTVILDTKYGQVRGLQRKTVYDKEPYF-----AFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNC 89
            |.|.|:|||||:|.|:|...       |     ||.|||||:||:|||||:.|.|.:||..:.|.
Frog    28 GETDIVDTKYGKVTGVQISV-------FSGIITAFLGIPYAEPPIGDLRFKKPVPHKPWSEIWNA 85

  Fly    90 TTNRSKPMQ-----------RNMLLGIVEGSEDCLHLNVYVKALKSEKPLPVIVWIYGGGFQKGE 143
            :...:...|           ..|.....:.|||||:||:::...| .:...|:||||||.|:.|.
Frog    86 SQYGNSCYQTVDQIFPGFSGAEMWNPNTQLSEDCLYLNIWIPTPK-PRNASVMVWIYGGSFETGT 149

  Fly   144 ASRDIYSPDYFMK-KPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFN 207
            :|.|:|...:..: :.|:.|::||||.|||||:..... :.|||.||.||.:||:|:.:|||.|.
Frog   150 SSLDLYDGKFLARTERVIVVSMNYRLGALGFLAFPGNN-EAPGNVGLFDQRLALQWVYENIAAFG 213

  Fly   208 GDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEW---VESPDNNWAFRLAQ--N 267
            |:|.:||:.|||||.|||...|.:.::.|.|.:|||||..|.:.|   .::..:|.|..||.  |
Frog   214 GNPKSITIFGESAGGASVSYHMLSPKSHGFFTRAIMQSATANAPWAVITKAEASNRALTLANLLN 278

  Fly   268 LGYKGDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSFLLFAFGPVIEPYETDHCVVPKRHKD 332
            ..|:   .:.::::.|......:|.   :..:::...||.:...|.|.::             .|
Frog   279 CFYR---NETEIIACLRNKSPEEIF---EKAVSVLPHRSVIEVNFPPTVD-------------GD 324

  Fly   333 LLSEAWGNDIP--------------VIVGGNSFEGLFSYQLVRKDPWALKNFHNILPREVRETSS 383
            .|.|     :|              ::.|.|..||  ||.||...|...|:..:.:.|    |..
Frog   325 FLIE-----MPEILMQLGQLKKKTQILTGVNKDEG--SYFLVYGLPGFSKDHESFINR----TQF 378

  Fly   384 LEGQDLLVRRLKQLYFNNEMQESMEMFEALNIFSHRQIWHD---THRFILARQSYAP-----KTP 440
            .:...|...:..:|..::.:.......:..|...:|....|   .:.||.....:..     ...
Frog   379 HKSVKLAFPKATELAIDSVLFHYTNWEDEQNPSHNRDAMDDIVGDYNFICPLLEFTKWNSELGNN 443

  Fly   441 TYLYRFDFDSPHFNQFRRLVCGDRIRGVAHADELSYLFYNIIASKLDKSSMEYKTIERMVGMWTS 505
            .|||.|     |....:....|  ..||.|..|:.::|...:..:|:.:..|......::..|.:
Frog   444 AYLYYF-----HHRSSKLTWPG--WMGVMHGYEIEFVFGIPMYRRLNYTKAEETLSRTLMRYWAN 501

  Fly   506 FASSGNPNCPELGSAKWEAVQLKENAVEKCFNISHDLEM--------RDLPESDCLAVWDTFYPR 562
            ||.:||||..:....:|....|.|         .|.|.:        |.:....| ..|:.|||:
Frog   502 FAKTGNPNGAQSSENRWPVFTLDE---------QHYLMLGTEDSKTNRKMRAKQC-RFWNNFYPK 556

Fly 563 562
Frog 557 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	154/534 (29%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	45/104 (43%)
bche	XP_002931610.1	COesterase	32..550	CDD:365897	160/573 (28%)
bche	XP_002931610.1	AChE_tetra	565..599	CDD:370053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910