DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est2 and LOC100493994

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	XP_004913616.1	Gene:	LOC100493994 / 100493994	-ID:	-	Length:	568	Species:	Xenopus tropicalis

Alignment Length:	578	Identity:	165/578 - (28%)
Similarity:	243/578 - (42%)	Gaps:	142/578 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ILDTKYGQVRGLQRKTVYDKEP---YFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTTNRSK 95
            :|.|||||:.|   .||..||.   ...|.|:|:||||:|.|||.||||||||..|...|.  :.
Frog    37 LLTTKYGQLLG---NTVGAKETDRLVHVFMGVPFAKPPIGPLRFEAPQPPEPWSSVREATA--AP 96

  Fly    96 PM----QRNM--LLGIVEG-------SEDCLHLNVYVKALKSEKP-LPVIVWIYGGGFQKGEASR 146
            ||    :|.|  |....:.       |||||:|||:..|.:.|.| |||:|:|:||....|.||.
Frog    97 PMCLQDKRGMEDLAEFFKAKFDFPPVSEDCLYLNVFTPADRGENPELPVMVFIHGGALTMGGASM 161

  Fly   147 DIYSPDYFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFNGDPN 211
             .........:.||.|:|.|||..:||.|..|.  :|.||.|..|||.||:|:..||..|.|:|.
Frog   162 -FEGSALCAYENVVVVSIQYRLGIMGFFSSGDK--EVRGNFGFLDQVAALQWVRDNIKDFGGNPQ 223

  Fly   212 NITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPDNNWAFRLAQNLGYKGDEKD 276
            ::|:.|||||..||...:.:..::|||||||.:||.|:...:.:                  .|.
Frog   224 SVTIFGESAGGVSVSAQVLSPLSKGLFHKAIAESGVAILPGLMT------------------SKT 270

  Fly   277 ADVLSFLSKV-------------CARQIAAIDQDVINLDEVRSFLLFAFGPVIEPYETDHCVVPK 328
            .::|..||.|             |.::  ..:.::|.:.....||:|       |...|...:||
Frog   271 EEILPLLSVVANISSCSVSDLVGCLKK--KTEDEIIAITAAMRFLVF-------PAVVDGVFLPK 326

  Fly   329 RHKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRKDPWALKNFHNILPREVRETSSLEGQDLLVRR 393
            ..:::|:....|.:|.::|.|:.|                 |..|||..:..|...||.:
Frog   327 PAEEILAAKESNPVPFLIGINNHE-----------------FGWILPLSLNITGYREGME----- 369

  Fly   394 LKQLYFNNEMQESMEMFEALNI------FSHRQIWHDT-------HRFI------------LARQ 433
                  ...:|.::.....||.      |...:.:.||       :.|:            |...
Frog   370 ------KKNIQATLGALPLLNTVSSAIPFIMEEYFGDTDDPKELRNNFLDLVGDIIFVIPALRTA 428

  Fly   434 SYAPKT--PTYLYRFDFDSPHFNQFRRLVCGDRIRGVAHADELSYLFYNIIASKLDKSSMEYKT- 495
            .|...:  |.|.|.|......:...:     |......|.|||    |.::.....||.:.:|:
Frog   429 KYHRDSGFPVYFYEFQHRPSMYADSK-----DDFVKADHGDEL----YFVVGGPFLKSGILFKSN 484

  Fly   496 --------IERMVGMWTSFASSGNPNCPELGSAKWEAVQLKENAVEKCFNISHDLEMR 545
                    .:.::..|.:||.:|:||  .||.|:|......|:.:|  .|::.....|
Frog   485 GTEEEKILSKTIMKYWANFARNGDPN--GLGLAEWPKYDEDEDYLE--INLTQKSSQR 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	160/554 (29%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	44/104 (42%)
LOC100493994	XP_004913616.1	COesterase	36..547	CDD:365897	165/578 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm47933
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000