DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and LOC100334697

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	XP_002661384.2	Gene:	LOC100334697 / 100334697	-ID:	-	Length:	576	Species:	Danio rerio

Alignment Length:	578	Identity:	169/578 - (29%)
Similarity:	260/578 - (44%)	Gaps:	82/578 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QQYRLSTGHTVILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVL 87
            |..|.:.|..:::  |.|.|:||    :.||.  :.|.|||:|.||||..|::||:|..||:||.
Zfish    42 QPSRTADGPKLLI--KDGLVQGL----LLDKS--YVFYGIPFADPPVGTSRWKAPRPVTPWKGVY 98

  Fly    88 NCTTNRSKPMQRNMLLGIV------EGSEDCLHLNVYVK-----ALKSEKPLPVIVWIYGGGFQK 141
            :.:..|:..||  ..:|.:      :.|||||:|||:|.     |....:||||::||:||.|..
Zfish    99 DASFPRAACMQ--ACIGPIADDCPKKVSEDCLYLNVFVPLSVDLATPLLQPLPVMLWIHGGDFIA 161

  Fly   142 GEASRDIYSPDYFMK-KPVVFVAINYRLAALGFL-SLKDPKLDVPGNAGLKDQVMALRWISQNIA 204
            |.||:.:|...:... ...|.|:|.|||.|.||| |.||||....||.|:.||..||.|:.||||
Zfish   162 GSASKPLYDGRFISNYTQTVIVSIAYRLGAFGFLVSGKDPKSTAVGNYGILDQQAALIWVQQNIA 226

  Fly   205 HFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQS---GCALSEWVESPDNNWAFRLAQ 266
            .|.|||:.:|:.|||||:.||.:.:..:.::.||.:|:.||   ...|....||......|..|.
Zfish   227 AFGGDPSRVTIFGESAGAQSVSLHLMIQSSKPLFKQAVFQSLPFSIPLKTRRESLKLGKHFAKAA 291

  Fly   267 NLGYKGDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSFLL---FAFGPVIE---PYETDHCV 325
            |...: |.|           |.:.::|  :||::.....|..|   |.|..|.|   |:.....:
Zfish   292 NCSLE-DMK-----------CLQSLSA--EDVLHAQIKTSSKLVNPFRFLEVFEIWGPFIDGELI 342

  Fly   326 VPKRHKDLLSEAWGNDIPVIVGGNSFEG-LFSYQLVRKDPWALKNFHNILPREVRETSSLEGQDL 389
            ..:.........|..:.||::|..|.|| :|.|.:.:|...|::  ..|....:.:..:::
Zfish   343 KEQAVSAFQKGHWQKEKPVLLGTTSEEGVIFVYGVFKKPVSAVE--CTIYTTAIFKQHAIK---- 401

  Fly   390 LVRRLKQLYFNNEMQESMEMFEALNIFSHRQIWHDTHRFILARQSYAPKTPTYLYRFDFDSPHFN 454
            ::|:...||.:.:.::.:.......||     |..:.|  .||.:....:..::|.||..|....
Zfish   402 ILRKYLPLYSDADRRDMLAQIVTDYIF-----WCPSRR--SARAAVLSGSSAWMYVFDQVSSDPR 459

  Fly   455 QFRRL-VCGDRIRGVAHADELSYLFYNIIASKLDKSSMEYKTIERMVGMWTSFASSGNPN----- 513
            .:..: .|..|   |.|..||.::|.:...:....:..|.....|::..|..||.:|||.
Zfish   460 VWSGVSSCYQR---VCHGAELPFVFDSASVANFSMTPAEKLLSNRVLCYWGGFAHTGNPTGETRR 521

  Fly   514 -------CPELGSAKWEAVQLKENAVEKCFNI-SHDLEMRDLPESDCLAVWDT--FYP 561
                   |.:.....|.:  ...|......|: :|........|..| ..|||  .||
Zfish   522 PSDISGFCRQQRPPSWPS--YTANRGWMIMNLTAHPHSQAGYGEDIC-DFWDTLGIYP 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	155/526 (29%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	51/110 (46%)
LOC100334697	XP_002661384.2	COesterase	44..569	CDD:278561	163/567 (29%)
LOC100334697	XP_002661384.2	Aes	<138..>245	CDD:223730	51/106 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575401
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940