DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and cel.2

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001120027.1	Gene:	cel.2 / 100144991	XenbaseID:	XB-GENE-1217488	Length:	552	Species:	Xenopus tropicalis

Alignment Length:	590	Identity:	169/590 - (28%)
Similarity:	250/590 - (42%)	Gaps:	106/590 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WPKL-IKMGAQLVGHKVQQYRLSTGHTV-ILDTKYGQVRGLQRKTVYDKEPYF-AFEGIPYAKPP 68
            |..| :.|...:|.|         ..|: ::.|:.|.|.|..:|.......|. .|:|||:|.||
Frog     4 WATLTLAMACLVVAH---------AKTLGVVHTEGGFVEGTNKKIGVVFPDYIDIFKGIPFAAPP 59

  Fly    69 VGDLRFRAPQPPEPWQGVLNCTTNRSKPMQRNMLLGIVEGSEDCLHLNVYVKALKSE--KPLPVI 131
               ..|...:....|.|.|.....:.:.:|..:....|.||.|||:|||:|...:|:  ..|||:
Frog    60 ---KPFEKAEKHPGWSGTLQAKDYKPRCLQATITQDNVFGSLDCLYLNVWVPQTRSQVSTNLPVM 121

  Fly   132 VWIYGGGFQKGEASRDIYSPDYF-------MKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGL 189
            |||:||||..|......:..:|.       |:..|:.|..|||:..|||||..|.  :.|||.||
Frog   122 VWIFGGGFLLGSGQGANFLSNYLYDGEEVAMRGKVIVVTFNYRVGPLGFLSTGDS--NAPGNYGL 184

  Fly   190 KDQVMALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEW-V 253
            .||.||:.|:.:|||.|.||||||||.|||||.|||.:...|....||..:||.|||..|..| :
Frog   185 WDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLTPYNVGLIKRAISQSGVGLCPWAI 249

  Fly   254 ESPDNNWAFRLAQNLG--YKGDEKDADVLSFLSKVCARQ------IAAIDQDVINLDEVRSFLLF 310
            :.....||..||..||  ....::.||        |.|.      ..|....:.||:......|
Frog   250 QRDPLTWAKSLASKLGCPVNNTKELAD--------CLRNTDPGALTIAYQLQLFNLEYPLVHYL- 305

  Fly   311 AFGPVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEG-LFS-YQLVRKDPWALKNFHNI 373
            |:.|||     |...:|...::|.|.|.|.|  .|.|.|:.:| ||: ..|    |...:..|.|
Frog   306 AYSPVI-----DGDFIPDEPRNLFSNAAGVD--YIAGVNNMDGHLFAGVDL----PAINQPLHKI 359

  Fly   374 LPREVRE-------TSSLEGQDLLVRRLKQLYFNNEMQESME----------MF-----EALNIF 416
            ...:|::       ...:...|:........:..|..||.|:          :|     |||.:.
Frog   360 STEQVQKVVRGLTLAKGVPALDIAYDLYTAGWGTNPSQEDMKRTVVEVETDYIFLVATQEALALH 424

  Fly   417 SHRQIWHDTHRFILARQSYAPKTPTYLYRFDFDSPHFNQFRRLVCGDRIRGVAHADELSYLFYNI 481
            ........|:.::.:..|..|..|:::                       |..||::|.::|...
Frog   425 YQNAKGAKTYSYMFSHPSRMPVYPSWM-----------------------GADHAEDLQFMFGKP 466

  Fly   482 IASKLDKSSMEYKTIERMVGMWTSFASSGNPNCPELG-SAKWEAVQLKENAVEKCFNISHDLEMR 545
            .::.|.....:....:.|:..||:||::|:|:..|.. ...|.|.. .||.  :...|:|.:..:
Frog   467 FSTPLAYRPRDRDVAQYMIAYWTNFAATGDPSKGESSIPTPWLAYS-TENG--QYLEINHKINYQ 528

  Fly   546 DLPES 550
            .:.:|
Frog   529 SMKQS 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	157/535 (29%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	52/112 (46%)
cel.2	NP_001120027.1	COesterase	24..542	CDD:365897	163/561 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000