DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est2 and Ces1f

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001096829.2	Gene:	Ces1f / 100125372	RGDID:	1642419	Length:	561	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	165/548 - (30%)
Similarity:	247/548 - (45%)	Gaps:	94/548 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLN-------CTT 91
            ::||..|:|.|.........:....|.|:|:||||:|.|||..|||.|||..|.|       |:.
  Rat    25 VVDTTKGKVLGKYVSLEGVTQSVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTTYPPMCSQ 89

  Fly    92 NRSKPMQRNMLLG------IVEGSEDCLHLNVYVKA-LKSEKPLPVIVWIYGGGFQKGEASR--- 146
            :.:|..:.|.||.      .:|.|||||:||:|..| ......|||:|||:|||...|.||.
  Rat    90 DAAKGQRMNDLLTNRKEKIHLEFSEDCLYLNIYTPADFTKNSRLPVMVWIHGGGMTLGGASTYDG 154

  Fly   147 ---DIYSPDYFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFNG 208
               ..|       :.||.|||.|||...||.|..|.  ...||.|..|||.||.|:..|||:|.|
  Rat   155 RVLSAY-------ENVVVVAIQYRLGIWGFFSTGDE--HSRGNWGHLDQVAALHWVQDNIANFGG 210

  Fly   209 DPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPDNNWAFRLAQNLGYKGD 273
            ||.::|:.|||||..||.|::.:..|:.|||:||.:||......:.:.|...|.:...::.....
  Rat   211 DPGSVTIFGESAGGFSVSVLVLSPLTKNLFHRAISESGVVFLPGLLTKDVRPAAKQIADMAGCET 275

  Fly   274 EKDADVLSFLSKVCARQIAAI--DQDVINLDEVRSFLLFAFGPVIEPYE-----TDHCVVPKRHK 331
            ...|.::..|.:....::..|  ..::|.|...|...        |.|.     .|:.|:||..|
  Rat   276 TTSAIIVHCLRQKTEEELLEIMKKMNLIKLSSQRDNK--------ESYHFLSTVVDNVVLPKDPK 332

  Fly   332 DLLSEAWGNDIPVIVGGNSFE-GLFSYQLVRKDPWALKNFHNILPREV-----------RETSSL 384
            ::|:|...|.:|.|||.|..| |           |.|......:|.:|           .:.:||
  Rat   333 EILAEKNFNTVPYIVGINKQECG-----------WLLPTMMGFVPADVELDKKMAITLLEKFASL 386

  Fly   385 EG--QDLLVRRLKQLYFNNEMQESMEMFEALNIFSHRQIWHDTHRFILARQSYAPKTPTYLYRF- 446
            .|  :|::...:::  :.....:|:::.:.:..|. ..:.......:::|.......|||:|.:
  Rat   387 YGIPEDIIPVAIEK--YRKGSDDSIKIRDGILAFI-GDVSFSIPSVMVSRDHRDAGAPTYMYEYQ 448

  Fly   447 ---DFDSPHFNQFRRLVCGDRIRGVAHADELSYLFYNIIASKL--DKSSMEYKTIERMV-GMWTS 505
               .|.||   |..:.|.||      |||:|    |::..:.:  |.:|.|...:.:|| ..|.:
  Rat   449 YYPSFSSP---QRPKHVVGD------HADDL----YSVFGAPILRDGASEEEIKLSKMVMKFWAN 500

  Fly   506 FASSGNPNCPELGSAKWEAVQLKENAVE 533
            ||.:||||  ..|...|.....||..::
  Rat   501 FARNGNPN--GRGLPHWPQYDQKEEYLQ 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	162/536 (30%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	47/110 (43%)
Ces1f	NP_001096829.2	COesterase	24..545	CDD:278561	165/548 (30%)
		Aes	<121..>234	CDD:223730	52/121 (43%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336517
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm44890
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.650