Protein Alignment alpha-Est3 and CES2

DIOPT Version :10

• Sequence 1: NP_524267.2
• Gene: alpha-Est3 / 40907
• FlyBaseID: FBgn0015571
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_003860.3
• Gene: CES2 / 8824
• HGNCID: 1864
• Length: 559
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 157/580 - (27%)
• Similarity: 242/580 - (41%)
• Gaps: 121/580 - (20%)

  Fly     8 TTSGPVLGKQC------TGVYGDEYVSFERIPYAQPPVGHLRFMAPLPVEPWSQPLDCTKPGQKP 66
            |.:|.|||...      .||.     :|..||:|:||:|.|||..|.|.|.||...|.|......
Human    36 THTGQVLGSLVHVKGANAGVQ-----TFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMC 95

  Fly    67 L------------QFNHYSKQLEGVEDCLYLNVYA-KELDSPRPLPLIVFFFGGGFEKGDPTKEL 118
            |            |||.........||||||::|. ........||::|:..||....|  ...|
Human    96 LQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFG--MASL 158

  Fly   119 HSPDYF-MMRDVVVVTVSYRVGPLGFLSLNDPAVGVPGNAGLKDQLLAMEWIKENAERFNGDPKN 182
            :..... .:.:||||.:.||:|.|||.|..|.  ...||.|..||:.|:.|:::|...|.|:|..
Human   159 YDGSMLAALENVVVVIIQYRLGVLGFFSTGDK--HATGNWGYLDQVAALRWVQQNIAHFGGNPDR 221

  Fly   183 VTAFGESAGAASVHYLMLNPKAEGLFHKAILQSGNVLCSWALCTIKNLPHRLAVNLGMESAEHVT 247
            ||.||||||..||..|:::|.::||||.||::||..|....:.:..::...:..||  .:.:.|.
Human   222 VTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANL--SACDQVD 284

  Fly   248 DAMVLDFLQKLPGEKLV---RPYLLSAEEHLDDCVFQFGPMVEPYKTEHCALPNHPQELLDKAWG 309
            ...::..|:....|:::   :|:.:.                 |...:...||.||||||..|..
Human   285 SEALVGCLRGKSKEEILAINKPFKMI-----------------PGVVDGVFLPRHPQELLASADF 332

  Fly   310 NRIPVLMSGTSFE-GLLMYARVQMAPYLLTSLKKEPEHMLPLDVKRNLPQ-----ALARHL---- 364
            ..:|.::...:.| |.|:                 |:.|...|.::.:.:     ||.:.|
Human   333 QPVPSIVGVNNNEFGWLI-----------------PKVMRIYDTQKEMDREASQAALQKMLTLLM 380

  Fly   365 -----GQRLQETHFGGNDPSAMSPESLKA-YCEYASYKVFWHPILKTLRSRVKSSSASTYLYRFD 423
                 |..|:|.:.|.|.    .|::|:| :.|..:..:|..|.|:.  :..:.|.|..|.|.
Human   381 LPPTFGDLLREEYIGDNG----DPQTLQAQFQEMMADSMFVIPALQV--AHFQCSRAPVYFYE-- 437

  Fly   424 FDSPTFNHQR--LKYCGDKLRGVAHVDDHSYLWYGDFSWKLDKHTPEFLTIER-MIDMLTSFART 485
                 |.||.  ||..........|.|:..:::...|.....|.|.|...:.| |:....:|||.
Human   438 -----FQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARN 497

  Fly   486 SNPNCKLIQDQLP------RAKEWKPLNSKSAL-ECLN----------ISENIKMMELPE 528
            .|||    .:.||      :.:::..||.:.|: ..|.          :.:.|:.:|.||
Human   498 GNPN----GEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPE 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est3	NP_524267.2	alpha/beta hydrolases	2..535	CDD:473884	157/580 (27%)
CES2	NP_003860.3	COesterase	30..538	CDD:395084	153/563 (27%)
		Prevents secretion from ER. /evidence=ECO:0000255	556..559