Protein Alignment alpha-Est3 and NLGN3

DIOPT Version :10

• Sequence 1: NP_524267.2
• Gene: alpha-Est3 / 40907
• FlyBaseID: FBgn0015571
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Alignment Length: 635
• Identity: 153/635 - (24%)
• Similarity: 250/635 - (39%)
• Gaps: 157/635 - (24%)

  Fly     6 VNTTSGPVLGKQC---TGVYG--DEYVSFERIPYAQPPVGHLRFMAPLPVEPWSQPLDCTK-PGQ 64
            |||..|.:.|.:.   :.:.|  |:|:.   :|||.||:|..||:.|.|...||...:.|. |..
Human    44 VNTHFGKLRGARVPLPSEILGPVDQYLG---VPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPV 105

  Fly    65 KPLQFN----------HYSKQLEGV--------EDCLYLNVYAKELDSPR--------------- 96
            .|...:          .::..|:.|        |||||||||....|..|
Human   106 CPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICR 170

  Fly    97 ----------------------------PLPLIVFFFGGGFEKGDPTKELHSPDYFMMRDVVVVT 133
                                        ..|::|:..||.:.:|.... :.........:|:|:|
Human   171 KGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNM-IDGSILASYGNVIVIT 234

  Fly   134 VSYRVGPLGFLSLNDPAVGVPGNAGLKDQLLAMEWIKENAERFNGDPKNVTAFGESAGAASVHYL 198
            ::||||.|||||..|.|  ..||.||.||:.|:.|:.||...|.|||:.:|.||...||:.|..|
Human   235 LNYRVGVLGFLSTGDQA--AKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLL 297

  Fly   199 MLNPKAEGLFHKAILQSGNVLCSWALCTIKNLPHRLAVNLGMESAEHVTDAM-VLDFLQKLPGEK 262
            .|:..:||||.:||:|||:.|.|||   :...|.:....|..:...:|.|.: ::|.|::...::
Human   298 TLSHHSEGLFQRAIIQSGSALSSWA---VNYQPVKYTSLLADKVGCNVLDTVDMVDCLRQKSAKE 359

  Fly   263 LVRPYLLSAEEHLDDCVFQFGPMVEPYKTEHCALPNHPQELLDKAWGNRIPVLMSGTSFEGLLMY 327
            ||...:..|..|:     .|||::     :...:|:.|:.|:::.......:::.....|||...
Human   360 LVEQDIQPARYHV-----AFGPVI-----DGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFV 414

  Fly   328 ARV-------------QMAPYLLTSLKKEPEHMLPLDVKRNLPQALARHLGQRLQETHFGGNDPS 379
            ..|             ......:.:|...||.      |..|.:.:      :...|.:...|
Human   415 EGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEG------KDTLRETI------KFMYTDWADRD-- 465

  Fly   380 AMSPESLKAYCEYASYKVFWHPILKTL------RSRVKSSSASTYLYRFDFDSPTFNHQRLKYCG 438
              :||:.:                |||      ...|:.|..:..|:. .:.|||:.:....:|.
Human   466 --NPETRR----------------KTLVALFTDHQWVEPSVVTADLHA-RYGSPTYFYAFYHHCQ 511

  Fly   439 DKLR----GVAHVDDHSYLWYGDFSWKLDKHTPEFLTIERMIDML-----TSFARTSNPN----- 489
            ..::    ..||.|:..|::........|.....|...:.|:..:     |:||:|.:||
Human   512 SLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQ 576

  Fly   490 -CKLIQDQLPRAKE--WKPLNSKSALECLNISENIKMMELPELQKLRVWE 536
             .|.|..:..|.:|  |...|.:..| .|:|....::.:.....|:..|:
Human   577 DTKFIHTKANRFEEVAWSKYNPRDQL-YLHIGLKPRVRDHYRATKVAFWK 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est3	NP_524267.2	alpha/beta hydrolases	2..535	CDD:473884	152/632 (24%)
NLGN3	NP_851820.1	COesterase	40..624	CDD:395084	152/632 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		0/24 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694