Protein Alignment alpha-Est3 and Ces3a

DIOPT Version :10

• Sequence 1: NP_524267.2
• Gene: alpha-Est3 / 40907
• FlyBaseID: FBgn0015571
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_941074.1
• Gene: Ces3a / 382053
• MGIID: 102773
• Length: 571
• Species: Mus musculus
• Alignment Length: 585
• Identity: 166/585 - (28%)
• Similarity: 248/585 - (42%)
• Gaps: 118/585 - (20%)

  Fly     5 QVNTTSGPVLGKQCTGVYGDEYVS-FERIPYAQPPVGHLRFMAPLPVEPW--------SQPL--- 57
            :|:|..|.|.|:|......|..|: |..||:||.|:|.|||.||||.:||        :.|:
Mouse    38 EVDTPLGRVRGRQVGVKDTDRMVNVFLGIPFAQAPLGPLRFSAPLPPQPWEGVRDASINPPMCLQ 102

  Fly    58 DCTKPGQKPLQFNHYSKQLEGVEDCLYLNVYA-KELDSPRPLPLIVFFFGGGFEKGDPTKELHSP 121
            |..:........|...|.....||||.||:|: .|:.:....|::|:..||....|..|    |.
Mouse   103 DVERMSNSRFTLNEKMKIFPISEDCLTLNIYSPTEITAGDKRPVMVWIHGGSLLVGSST----SH 163

  Fly   122 DYFMMR---DVVVVTVSYRVGPLGFLSLNDPAVGVPGNAGLKDQLLAMEWIKENAERFNGDPKNV 183
            |...:.   |||||||.||:|..||||..|.  .:|||.|..|.:.|:.|::.|...|.|||..|
Mouse   164 DGSALAAYGDVVVVTVQYRLGIFGFLSTGDK--HMPGNRGFLDVVAALRWVQGNIAPFGGDPNCV 226

  Fly   184 TAFGESAGAASVHYLMLNPKAEGLFHKAILQSGNV-------LCSWALCTIKNLPHRLAVNLGME 241
            |.||.|||...|..|:|:|.:.||||:||.|||.|       |.:|:  ..:|..:.:|  .|..
Mouse   227 TIFGNSAGGIIVSSLLLSPMSAGLFHRAISQSGVVISKILEDLNAWS--EAQNFANSVA--CGSA 287

  Fly   242 SAEHVTDAMVLDFLQKLPGEKLVRPYLLSAEEHLDDCVFQFGPMVEPYKTEHCALPNHPQELLDK 306
            |...:...:    ||| .|:.|:....::....::|..|                |..||:||..
Mouse   288 SPAELVQCL----LQK-EGKDLITKKNVNISYTVNDSFF----------------PQRPQKLLAN 331

  Fly   307 AWGNRIPVLMSGTSFE-GLLMYARVQMAPYLLTSLKKEPEHMLPLDVKRNLPQALAR-HLGQRLQ 369
            .....:|.|:..|:.| |.|:..        ..::..:.||:...|:..|....||. .|...:.
Mouse   332 KQFPTVPYLLGVTNHEFGWLLLK--------FWNILDKMEHLSQEDLLENSRPLLAHMQLPPEIM 388

  Fly   370 ETHF-----GGNDPSAMSPESLKAYCEYASYKVFWH--PILKTL--RSRVKSSSASTYLYRFDFD 425
            .|..     .|:|.||         ..||..::...  .::.||  ...::.:....:||.|...
Mouse   389 PTVIDEYLDNGSDESA---------TRYALQELLGDITLVIPTLIFSKYLQDAGCPVFLYEFQHT 444

  Fly   426 SPTFNHQRLKYCGDKLRGVAHVDDHSYLWYGDFSWKLDKHT----PEFLTIERMIDML-----TS 481
            ..:|  .:.|....|   ..|..::::::.|.|  ..|:.:    ||....|:.:.:.     :.
Mouse   445 PSSF--AKFKPAWVK---ADHSSENAFVFGGPF--LTDESSLLAFPEATEEEKQLSLTMMAQWSQ 502

  Fly   482 FARTSNPNCKLIQDQLPRAKEWKPLNS-KSALEC-LNISENIKMME---------LPELQKLRVW 535
            ||||.|||.|    .||   .|..||. :..||. |.....:|:.:         ||  :|::.|
Mouse   503 FARTGNPNGK----GLP---PWPQLNQLEQYLEIGLEPRTGVKLKKGRLQFWTETLP--RKIQEW 558

  Fly   536  535
            Mouse   559  558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est3	NP_524267.2	alpha/beta hydrolases	2..535	CDD:473884	165/583 (28%)
Ces3a	NP_941074.1	COesterase	36..547	CDD:395084	162/570 (28%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571