Protein Alignment alpha-Est3 and Nceh1

DIOPT Version :10

• Sequence 1: NP_524267.2
• Gene: alpha-Est3 / 40907
• FlyBaseID: FBgn0015571
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_848887.1
• Gene: Nceh1 / 320024
• MGIID: 2443191
• Length: 408
• Species: Mus musculus
• Alignment Length: 463
• Identity: 90/463 - (19%)
• Similarity: 149/463 - (32%)
• Gaps: 196/463 - (42%)

  Fly    47 PLP---VEPWS-QPLDCTKPGQK-------PLQFNH-----------YSKQ-------------- 75
            |||   .:||. ..||.|..|.:       .|..||           :.||
Mouse    22 PLPSAVSDPWKLMLLDATFRGAQQVSNLIHSLGLNHHLIALNFIITSFGKQSARSSPKVKVTDTD 86

  Fly    76 LEGVEDCLYLNVYAKELDSPRP-LPL---IVFFFGGGFEKGDP------------TKELHSPDYF 124
            .:|||    :.|:.   .||:| .||   :::..|||:.....            .:||::
Mouse    87 FDGVE----VRVFE---GSPKPEEPLRRSVIYIHGGGWALASAKISYYDQLCTTMAEELNA---- 140

  Fly   125 MMRDVVVVTVSYRVGPLGFLSLNDPAVGVPGNAGLKDQLLAMEWI--KENAERFNGDPKNVTAFG 187
                 |:|::.||:         .|.|..|..  :.|.:.|.::.  .|..:::..||..|...|
Mouse   141 -----VIVSIEYRL---------VPQVYFPEQ--IHDVIRATKYFLQPEVLDKYKVDPGRVGISG 189

  Fly   188 ESAGAASVHYLMLNPKAEGLFHKAILQSGNVLCSWALCTIKNLPHRLAVNLGMESAEHVTDAMVL 252
            :|||                        ||                ||..||.:.      ..|.
Mouse   190 DSAG------------------------GN----------------LAAALGQQF------TYVA 208

  Fly   253 DFLQKLPGEKLVRPYLLSAEEHLDDCVFQFGPMVEPYKTEHCALPNHPQELLDKAW-----GN-- 310
            ....||..:.||.|.|.:.:.:            .|...:....|..|:.::.:.|     ||
Mouse   209 SLKNKLKLQALVYPVLQALDFN------------TPSYQQSMNTPILPRHVMVRYWLDYFKGNYD 261

  Fly   311 --RIPVLMSGTSFE---GLLMYARVQMAPYLLTSLKKEPEHMLPLD----VKRNLPQALARHLGQ 366
              ...::.:.||.:   ...:.||:.....|.:|:||..:.::...    :.:.:||.|
Mouse   262 FVEAMIVNNHTSLDVERAAALRARLDWTSLLPSSIKKNYKPIMQTTGNARIVQEIPQLL------ 320

  Fly   367 RLQETHFGGNDPSAMSP--------ESL-KAY---CEYASYKVFWHPILK----TLRSRVKSSSA 415
                       .:|.||        |:| |.|   ||        |.:|:    ....|::|:..
Mouse   321 -----------DAAASPLIAEQEVLEALPKTYILTCE--------HDVLRDDGIMYAKRLESAGV 366

  Fly   416 STYLYRFD 423
            :..|..|:
Mouse   367 NVTLDHFE 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est3	NP_524267.2	alpha/beta hydrolases	2..535	CDD:473884	90/463 (19%)
Nceh1	NP_848887.1	Abhydrolase_3	109..381	CDD:400284	67/369 (18%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	113..115		0/1 (0%)