Protein Alignment alpha-Est3 and Nceh1

DIOPT Version :10

• Sequence 1: NP_524267.2
• Gene: alpha-Est3 / 40907
• FlyBaseID: FBgn0015571
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_001120996.1
• Gene: Nceh1 / 294930
• RGDID: 1311104
• Length: 408
• Species: Rattus norvegicus
• Alignment Length: 457
• Identity: 85/457 - (18%)
• Similarity: 143/457 - (31%)
• Gaps: 184/457 - (40%)

  Fly    47 PLP---VEPWS-QPLDCTKPGQK-------PLQFNHY-----------------SKQLEGVEDCL 83
            |||   .:||. ..||.|..|.:       .|..:|:                 |.....|.|..
  Rat    22 PLPSAVSDPWKLMLLDATFRGAQQVSNLIHSLGLSHHLITLNFIIISFGKKSARSSPRVKVTDTD 86

  Fly    84 YLNVYAKELDSPRPLP------LIVFFFGGGFEKGDP------------TKELHSPDYFMMRDVV 130
            :..|..:..:.| |.|      .:|:..|||:.....            .:||::         |
  Rat    87 FDGVEVRVFEGP-PKPDEPLRRSVVYIHGGGWALASAKISYYDQLCTAMAEELNA---------V 141

  Fly   131 VVTVSYRVGPLGFLSLNDPAVGVPGNAGLKDQLLAMEWI--KENAERFNGDPKNVTAFGESAGAA 193
            :|::.||:         .|.|..|..  :.|.:.|.::.  .|..:::..||..|...|:|||
  Rat   142 IVSIEYRL---------VPQVYFPEQ--IHDVIRATKYFLQPEVLDKYKVDPGRVGVSGDSAG-- 193

  Fly   194 SVHYLMLNPKAEGLFHKAILQSGNVLCSWALCTIKNLPHRLAVNLGMESAEHVTDAMVLDFLQKL 258
                                  ||                ||..||.:.      ..|.....||
  Rat   194 ----------------------GN----------------LAAALGQQF------TYVESLKNKL 214

  Fly   259 PGEKLVRPYLLSAEEHLDDCVFQFGPMVEPYKTEHCALPNHPQELLDKAW-----GN----RIPV 314
            ..:.|:.|.|.:.:.:            .|...:....|..|:.::.:.|     ||    ...:
  Rat   215 KLQALIYPVLQALDFN------------TPSYQQSMNTPILPRHVMVRYWVDYFKGNYDFVEAMI 267

  Fly   315 LMSGTSFE---GLLMYARVQMAPYLLTSLKKEPEHML----PLDVKRNLPQALARHLGQRLQETH 372
            :.:.||.:   ...:.||:.....|.:|:||..:.:|    ...:.:.:||.|
  Rat   268 VNNHTSLDVERAAALRARLDWTSLLPSSIKKNYKPVLQTIGDARIVKEIPQLL------------ 320

  Fly   373 FGGNDPSAMSP-----ESLKAY-------CEYASYKVFWHPILK----TLRSRVKSSSASTYLYR 421
                 .:|.||     |.|:|.       ||        |.:|:    ....|::|:..:..|..
  Rat   321 -----DAAASPLIAEQEVLQALPKTYILTCE--------HDVLRDDGIMYAKRLESAGVNVTLDH 372

  Fly   422 FD 423
            |:
  Rat   373 FE 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est3	NP_524267.2	alpha/beta hydrolases	2..535	CDD:473884	85/457 (19%)
Nceh1	NP_001120996.1	Abhydrolase_3	109..381	CDD:400284	67/369 (18%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	113..115		0/1 (0%)