Protein Alignment alpha-Est3 and Ces1e

DIOPT Version :10

• Sequence 1: NP_524267.2
• Gene: alpha-Est3 / 40907
• FlyBaseID: FBgn0015571
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_113753.2
• Gene: Ces1e / 29225
• RGDID: 621508
• Length: 561
• Species: Rattus norvegicus
• Alignment Length: 587
• Identity: 174/587 - (29%)
• Similarity: 255/587 - (43%)
• Gaps: 118/587 - (20%)

  Fly     6 VNTTSGPVLGKQCTGVYGDEYVSFE----------RIPYAQPPVGHLRFMAPLPVEPW------- 53
            |:|..|.||||         |||.|          .:|:|:||:|.|||..|.|.|||
  Rat    26 VDTLQGKVLGK---------YVSLEGFTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTT 81

  Fly    54 SQPLDCTK---PGQ--KPLQFNHYSK-QLEGVEDCLYLNVYA-KELDSPRPLPLIVFFFGGGFEK 111
            |.|..|::   .||  ..|..|.... .|:..|||||||:|. .:|.....||::|:..|||...
  Rat    82 SYPPMCSQDPVAGQIVNDLLTNREENISLQFSEDCLYLNIYTPADLTKRDRLPVMVWIHGGGLVL 146

  Fly   112 GDPTK------ELHSPDYFMMRDVVVVTVSYRVGPLGFLSLNDPAVGVPGNAGLKDQLLAMEWIK 170
            |..:.      ..|       .:||||.:.||:|..||.|..|.  ...||.|..||:.|:.|::
  Rat   147 GGASTYDGLALSTH-------ENVVVVVIQYRLGIWGFFSTGDE--HSRGNWGHLDQVAALHWVQ 202

  Fly   171 ENAERFNGDPKNVTAFGESAGAASVHYLMLNPKAEGLFHKAILQSGNVLCSWALCTIKN---LPH 232
            :|.:.|.|||.:||.||||||..||..|:|:|.|:.||||||.:||..|.  |....||   |..
  Rat   203 DNIDNFGGDPGSVTIFGESAGGESVSVLVLSPLAKNLFHKAISESGVALT--AGLVKKNTRPLAE 265

  Fly   233 RLAVNLGMESAEHVTDAMVLDFLQKLPGEKL---VRPYLLSAEEHLDDCVFQFGPMVEPYKTEHC 294
            ::||..|.:|.  .:.|||....||...|.|   ::..|.|.:.|.|.  .|..|.| |...:..
  Rat   266 KIAVVSGCKST--TSAAMVHCLRQKTEEELLETTLKLNLFSLDLHGDS--RQSYPFV-PTVLDGV 325

  Fly   295 ALPNHPQELLDKAWGNRIPVLMS------GTSFEGLLMY--ARVQMAPYLLTSLKKE-------P 344
            .||..|:|:|.:...|.:|.::.      |.....::.|  :.:::.|...|||.|:       |
  Rat   326 VLPKMPEEILAEKDFNTVPYIVGINKQEFGWILPTMMNYPPSDMKLDPMTATSLLKKSSFLLNLP 390

  Fly   345 EHMLPLDVKRNLPQALARHLGQRLQETHFGGNDPSAMSPESLKAYCEYASYKVFWHPILKTLRSR 409
            |..:|:.|::.|     ||.           :||.....:.|    |.....:|..|.:...|..
  Rat   391 EEAIPVAVEKYL-----RHT-----------DDPDRNKDQLL----ELIGDVIFGVPSVIVSRGH 435

  Fly   410 VKSSSASTYLYRFDFDSPTFNHQRLKYCGDKLRGVAHVDDHSYLWYGDFSWKLDK--HTPEFLTI 472
             :.:.|.||:|.|.: .|:|:        .|::....|.||....|..|...:.:  .:.|.:.:
  Rat   436 -RDAGARTYMYEFQY-RPSFS--------SKMKPSTVVGDHGDEIYSVFGAPILRGGTSKEEINL 490

  Fly   473 ER-MIDMLTSFARTSNPNCKLIQDQLPRAKEWKPLNSKSALECLNISENIKMMELPELQKLRVWE 536
            .: |:....:|||..|||    ...||   .|...:.|...  |.|....:..:..:.:::..|.
  Rat   491 SKMMMKFWANFARNGNPN----GQGLP---HWPEYDQKEGY--LQIGATTQQAQKLKEKEVAFWS 546

  Fly   537 SV 538
            .:
  Rat   547 EL 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est3	NP_524267.2	alpha/beta hydrolases	2..535	CDD:473884	173/582 (30%)
Ces1e	NP_113753.2	COesterase	24..545	CDD:395084	173/582 (30%)
		Prevents secretion from ER. /evidence=ECO:0000255	558..561