Protein Alignment alpha-Est3 and CES3

DIOPT Version :10

• Sequence 1: NP_524267.2
• Gene: alpha-Est3 / 40907
• FlyBaseID: FBgn0015571
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_079198.2
• Gene: CES3 / 23491
• HGNCID: 1865
• Length: 571
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 169/560 - (30%)
• Similarity: 245/560 - (43%)
• Gaps: 121/560 - (21%)

  Fly     5 QVNTTSGPVLGKQCTGVYG-DEYVS-FERIPYAQPPVGHLRFMAPLPVEPWSQPLDCTKPGQKPL 67
            :|:||.|.|.|:| .||.| |..|: |..||:||||:|..||.||.|.:||....|.:......|
Human    35 EVDTTLGRVRGRQ-VGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCL 98

  Fly    68 Q----FNHYSKQLEG-------VEDCLYLNVYA-KELDSPRPLPLIVFFFGGGFEKGDPTKELHS 120
            |    .|.....|.|       .||||.||||: .|:.:....|::|:..||....|..|    |
Human    99 QDVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAAT----S 159

  Fly   121 PDYFMMR---DVVVVTVSYRVGPLGFLSLNDPAVGVPGNAGLKDQLLAMEWIKENAERFNGDPKN 182
            .|...:.   |||||||.||:|.|||.|..|.  ..|||.|..|.:.|:.|::||...|.||...
Human   160 YDGSALAAYGDVVVVTVQYRLGVLGFFSTGDE--HAPGNQGFLDVVAALRWVQENIAPFGGDLNC 222

  Fly   183 VTAFGESAGAASVHYLMLNPKAEGLFHKAILQSGNVLC-------SWALCTIKNLPHRLAVNLGM 240
            ||.||.|||.:.:..|:|:|.|.||||:||.|||.:..       .|.|.      .::|..|..
Human   223 VTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLA------QKIANTLAC 281

  Fly   241 ESAEHVTDAMVLDFLQKLPGEKLVRPYLLSAEEHLDDCVFQFGPMVEPYKTEHCALPNHPQELLD 305
            .|:   :.|.::..||:..||:||      ..:.|.:.::       |...:....|..|:|||.
Human   282 SSS---SPAEMVQCLQQKEGEELV------LSKKLKNTIY-------PLTVDGTVFPKSPKELLK 330

  Fly   306 KAWGNRIPVLMSGTSFE---------GLL----MYARVQM---APYLLTSLKKEPEHMLPLDVKR 354
            :...:.:|.||...:.|         |||    ..:|..|   :..:||||...||.|
Human   331 EKPFHSVPFLMGVNNHEFSWLIPRGWGLLDTMEQMSREDMLAISTPVLTSLDVPPEMM------- 388

  Fly   355 NLPQALARHLGQRLQETHFGGNDPSAMSPESLKAYCEYASYKVFWHPILKTLRSRVKSSSASTYL 419
              |..:..:||                |....:|.|:  :::.|...:.    ..|.:.|.|.||
Human   389 --PTVIDEYLG----------------SNSDAQAKCQ--AFQEFMGDVF----INVPTVSFSRYL 429

  Fly   420 YRFDFDSPT----FNHQRLKYCGDKLRGVA--HVDDHSYLWYGDFSWKLDKHT----PEFLTIER 474
            .  |..||.    |.|:...:...|...|.  |..:.::::.|.|  .:|:.:    ||....|:
Human   430 R--DSGSPVFFYEFQHRPSSFAKIKPAWVKADHGAEGAFVFGGPF--LMDESSRLAFPEATEEEK 490

  Fly   475 MIDML-----TSFARTSNPNCKLIQ--DQLPRAKEWKPLN 507
            .:.:.     |.||||.:||.|.:.  .|..:|:::..:|
Human   491 QLSLTMMAQWTHFARTGDPNSKALPPWPQFNQAEQYLEIN 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est3	NP_524267.2	alpha/beta hydrolases	2..535	CDD:473884	169/560 (30%)
CES3	NP_079198.2	COesterase	32..547	CDD:395084	169/560 (30%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571