Protein Alignment alpha-Est3 and Ces4a

DIOPT Version :10

• Sequence 1: NP_524267.2
• Gene: alpha-Est3 / 40907
• FlyBaseID: FBgn0015571
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_666325.2
• Gene: Ces4a / 234677
• MGIID: 2384581
• Length: 563
• Species: Mus musculus
• Alignment Length: 583
• Identity: 167/583 - (28%)
• Similarity: 251/583 - (43%)
• Gaps: 109/583 - (18%)

  Fly     8 TTSGPVLGKQCTGVYGDEYVS-FERIPYAQPPVGHLRFMAPLPVEPW-------SQPLDCTKP-- 62
            |..|.:.|||..  .||..:. |..||:::||||..||..|.|..||       :.|..|.:.
Mouse    38 TKHGILQGKQVH--VGDTPIQVFLGIPFSKPPVGTRRFAPPEPPLPWNGIRDATTYPPSCLQESW 100

  Fly    63 GQ---------KPLQFNHYSKQLEGVEDCLYLNVYAKELDSPRP-LPLIVFFFGGGFEKGDPTKE 117
            ||         |..::.|:|      ||||||||||..|....| ||::|:|.||.|..|. ...
Mouse   101 GQILSMYLNTRKQYKWLHFS------EDCLYLNVYAPVLAPGAPLLPVMVWFPGGAFLAGS-AST 158

  Fly   118 LHSPDYFMMRDVVVVTVSYRVGPLGFLSLNDPAVGVPGNAGLKDQLLAMEWIKENAERFNGDPKN 182
            ....:......||:|.:.||:|.|||.|..:.  ...||.||.||:.|:.|::||.|.|.|||.:
Mouse   159 YEGSELAARGKVVLVFLQYRLGILGFFSTGNS--HARGNWGLLDQIAALRWVQENIEAFGGDPDS 221

  Fly   183 VTAFGESAGAASVHYLMLNPKAEGLFHKAILQSGN-VLCSW----ALCTIKNLPHRLAVNLGMES 242
            ||.||:||||.||..||::|.|:||||:||.|||. ||.::    .|.:.|.:.|       :..
Mouse   222 VTLFGQSAGAMSVSGLMVSPLAQGLFHQAISQSGTAVLKAFITPDPLTSAKKIAH-------LAG 279

  Fly   243 AEHVTDAMVLDFLQKLPGEKLV----RPYLLSAEEHLD--DCVFQFGPMVEPYKTEHCALPNHPQ 301
            .:|.:..::::.|:.|..|::.    |.....|..|.|  :.|:...|:|     :....|..|.
Mouse   280 CDHNSTKVMVECLRSLSAEEVTLVSKRMSFFQANSHKDPKEIVWFLSPVV-----DGVVFPEDPV 339

  Fly   302 ELLDKAWGNRIPVLMSGTSFEGLLMYARVQMAPYLLTSLKKEPEHMLPLDVKRNLPQALAR--HL 364
            .||.:                     .:|:..||||.....|.|..||..:|..|.|.:..  ::
Mouse   340 VLLTR---------------------GQVKPVPYLLGVNNAEFEWNLPFLMKIQLNQRMMNQTNI 383

  Fly   365 GQRLQETHFGGNDPSAMSPESLKAYCEYASYKVFWHPILKTLRSR-VKSSSASTYLY------RF 422
            .:.|...:...|......|...:.|...|.....|    |..|:| :.....:|::|      |:
Mouse   384 NKILWSFNVLLNITKEQVPVVAREYLNDAISNHDW----KMFRNRLIDLIGDATFVYATLQAARY 444

  Fly   423 --DFDSPTFNHQRLKYCGDKL-----RGVAHVDDHSYLWYGDFSWKLDKHTPEFLTIERMIDMLT 480
              |..||.:.::...:....:     .|..|.|:.|||:...||........:..::: |:....
Mouse   445 HRDAGSPVYLYEFKHHASSGIIIKPYNGADHGDELSYLFGSPFSKGSSAGEEKEFSLQ-MMKYWA 508

  Fly   481 SFARTSNPNCKLIQDQLPRAKEWKPLNSKSALECLNISE--NIKMMELPELQKLRVWESVCQS 541
            :||.|.|||    .::||   .|...:.......|:...  .:|:.|    :|:..|..:.||
Mouse   509 NFAHTGNPN----GEKLP---YWPRFDKDEKYLQLDFDTRVGVKLKE----KKMAFWSQLRQS 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est3	NP_524267.2	alpha/beta hydrolases	2..535	CDD:473884	164/575 (29%)
Ces4a	NP_666325.2	COesterase	33..554	CDD:395084	164/575 (29%)