Protein Alignment alpha-Est3 and NLGN4Y

DIOPT Version :10

• Sequence 1: NP_524267.2
• Gene: alpha-Est3 / 40907
• FlyBaseID: FBgn0015571
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_001352513.1
• Gene: NLGN4Y / 22829
• HGNCID: 15529
• Length: 836
• Species: Homo sapiens
• Alignment Length: 613
• Identity: 152/613 - (24%)
• Similarity: 255/613 - (41%)
• Gaps: 133/613 - (21%)

  Fly     6 VNTTSGPVLGKQC---TGVYG--DEYVSFERIPYAQPPVGHLRFMAPLPVEPWSQPLDCTK---- 61
            |||..|.:.|.:.   :.:.|  ::|:.   :|||.||.|..||..|.....|:...:.|:
Human    48 VNTNYGKIQGLRTPLPSEILGPVEQYLG---VPYASPPTGERRFQPPESPSSWTGIRNATQFSAV 109

  Fly    62 -----------PGQKPLQFNHYSKQL-----EGVEDCLYLNVYA--------------------- 89
                       ....|:.|......|     :..|||||||:|.
Human   110 CPQHLDERFLLHDMLPIWFTTSLDTLMTYVQDQNEDCLYLNIYVPMEDGTNIKRNADDITSNDHG 174

  Fly    90 -----KELDSPRPLPLIVFFFGGGFEKGDPTKELHSPDYFMMRDVVVVTVSYRVGPLGFLSLNDP 149
                 .|.:|.:  |::|:..||.:.:|.... :.........:|:|:|::||:|.|||||..|.
Human   175 EDKDIHEQNSKK--PVMVYIHGGSYMEGTGNM-IDGSILASYGNVIVITINYRLGILGFLSTGDQ 236

  Fly   150 AVGVPGNAGLKDQLLAMEWIKENAERFNGDPKNVTAFGESAGAASVHYLMLNPKAEGLFHKAILQ 214
            |  ..||.||.||:.|:.||:||...|.||||.||.||..|||:.|..|.|:..:||||.|||:|
Human   237 A--AKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQ 299

  Fly   215 SGNVLCSWALCTIKNLPHR----LAVNLGMESAEHVTDAMVLDFLQKLPGEKLVRPYLLSAEEHL 275
            ||..|.|||   :...|.:    ||..:|....: .||  :::.|:....::|::..:..|..|:
Human   300 SGTALSSWA---VNYQPAKYTRILADKVGCNMLD-TTD--MVECLKNKNYKELIQQTITPATYHI 358

  Fly   276 DDCVFQFGPMVEPYKTEHCALPNHPQELLDKAWGNRIPVLMSGTSFEGLLMYARVQMAPYLLTSL 340
                 .|||::     :...:|:.||.|:::.......:::.....|||          ..:..:
Human   359 -----AFGPVI-----DGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGL----------KFVDGI 403

  Fly   341 KKEPEHMLPLDVKRNLPQALARHLGQRLQETHFGGNDPSAMSPESLK-AYCEYASYKVFWHP--- 401
            ....:.:.|.|...::         ....:..:|..:......|::| .|.::|..:   :|
Human   404 VDNEDGVTPNDFDFSV---------SNFVDNLYGYPEGKDTLRETIKFMYTDWADKE---NPETR 456

  Fly   402 -----ILKTLRSRVKSSSASTYLYRFDFDSPTFNHQRLKYCGDKLR----GVAHVDDHSYLW--- 454
                 .|.|....|..:.|:..|:. .:.|||:.:....:|..:::    ..||.|:..|::
Human   457 RKTLVALFTDHQWVAPAVATADLHA-QYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIP 520

  Fly   455 -YGD---FSWKLDKHTPEFLTIERMIDMLTSFARTSNPN------CKLIQDQLPRAKE--WKPLN 507
             .|.   ||....|:  :.:....::...|:||:|.:||      .|.|..:..|.:|  |...|
Human   521 MIGPTELFSCNFSKN--DVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYN 583

  Fly   508 SKSALECLNISENIKMMELPELQKLRVW 535
            .|..| .|:|....::.:.....|:..|
Human   584 PKDQL-YLHIGLKPRVRDHYRATKVAFW 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est3	NP_524267.2	alpha/beta hydrolases	2..535	CDD:473884	151/611 (25%)
NLGN4Y	NP_001352513.1	COesterase	44..610	CDD:395084	151/611 (25%)