Protein Alignment alpha-Est3 and Nlgn2

DIOPT Version :10

• Sequence 1: NP_524267.2
• Gene: alpha-Est3 / 40907
• FlyBaseID: FBgn0015571
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_942562.2
• Gene: Nlgn2 / 216856
• MGIID: 2681835
• Length: 836
• Species: Mus musculus
• Alignment Length: 604
• Identity: 160/604 - (26%)
• Similarity: 246/604 - (40%)
• Gaps: 120/604 - (19%)

  Fly     6 VNTTSGPVLG--KQCTGVYGDEYVSFERIPYAQPPVGHLRFMAPLPVEPWSQPLDCTK-PGQKPL 67
            |||..|.|.|  ::.........|.|..:|||.||:|..||..|.....|....:.|. |...|.
Mouse    44 VNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQ 108

  Fly    68 QFN----------HYSKQLEGV--------EDCLYLNVYAKELDSP----------RP------- 97
            ..:          .::..||..        |||||||:|....|.|          .|
Mouse   109 NLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRD 173

  Fly    98 ---LPLIVFFFGGGFEKGDPTKELHSPDYF-MMRDVVVVTVSYRVGPLGFLSLNDPAVGVPGNAG 158
               .|:::|..||.:.:|  |..:...... ...:|:|||::||:|.|||||..|.|  ..||.|
Mouse   174 SGKKPVMLFLHGGSYMEG--TGNMFDGSVLAAYGNVIVVTLNYRLGVLGFLSTGDQA--AKGNYG 234

  Fly   159 LKDQLLAMEWIKENAERFNGDPKNVTAFGESAGAASVHYLMLNPKAEGLFHKAILQSGNVLCSWA 223
            |.||:.|:.|:.||...|.|||:.:|.||..|||:.|:.|:|:..:||||.|||.|||..:.||:
Mouse   235 LLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWS 299

  Fly   224 LCTIKNLPHR--LAVNLGMESAEHVTDAMVLDFLQKLPGEKLVRPYLLSAEEHLDDCVFQFGPMV 286
            : ..:.|.:.  ||..:|.: .|..|:|  ::.|::....:||...:..|..|:     .|||:|
Mouse   300 V-NYQPLKYTRLLAAKVGCD-REDSTEA--VECLRRKSSRELVDQDVQPARYHI-----AFGPVV 355

  Fly   287 EPYKTEHCALPNHPQELLDKAWGNRIPVLMSGTSFEGLLMYA-------RVQMAPYLLT------ 338
                 :...:|:.|:.|:.:.......:|:.....|||....       .|..:.:..|
Mouse   356 -----DGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFVD 415

  Fly   339 SLKKEPEHMLPLDVKRNLPQALARHLGQRLQETHFGGNDPSAMSPESLKAYCEYASYKVFWHPIL 403
            :|...||..   ||.|..         .:...|.:...|...|..::|.|              |
Mouse   416 NLYGYPEGK---DVLRET---------IKFMYTDWADRDNGEMRRKTLLA--------------L 454

  Fly   404 KTLRSRVKSSSASTYLYRFDFDSPTFNHQRLKYCGDKLR----GVAHVDDHSYLWYGDFSWKLDK 464
            .|....|..:.|:..|:. |:.||.:.:....:|..:.|    ..||.|:..|::........|.
Mouse   455 FTDHQWVAPAVATAKLHA-DYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDL 518

  Fly   465 HTPEFLTIERMIDML-----TSFARTSNPN------CKLIQDQLPRAKE--WKPLNSKSALECLN 516
            ....|...:.|:..:     |:||:|.:||      .|.|..:..|.:|  |...|||.. :.|:
Mouse   519 FPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEK-QYLH 582

  Fly   517 ISENIKMMELPELQKLRVW 535
            |....::.:.....|:..|
Mouse   583 IGLKPRVRDNYRANKVAFW 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est3	NP_524267.2	alpha/beta hydrolases	2..535	CDD:473884	159/602 (26%)
Nlgn2	NP_942562.2	COesterase	42..601	CDD:395084	159/602 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661
		Required for interaction with LHFPL4. /evidence=ECO:0000269|PubMed:28279354	679..699
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836