Protein Alignment alpha-Est3 and Nlgn1

DIOPT Version :10

• Sequence 1: NP_524267.2
• Gene: alpha-Est3 / 40907
• FlyBaseID: FBgn0015571
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: XP_006535478.1
• Gene: Nlgn1 / 192167
• MGIID: 2179435
• Length: 863
• Species: Mus musculus
• Alignment Length: 639
• Identity: 159/639 - (24%)
• Similarity: 252/639 - (39%)
• Gaps: 156/639 - (24%)

  Fly     6 VNTTSGPVLG--KQCTGVYGDEYVSFERIPYAQPPVGHLRFMAPLPVEPWSQPLDCTK------- 61
            |.|..|.:.|  |:.........:.|..:|||.||.|..||..|.|..|||...:.|:
Mouse    55 VTTNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGEHRFQPPEPPSPWSDIRNATQFAPVCPQ 119

  Fly    62 ---PGQKP--LQFNHYSKQLEGV--------EDCLYLNVY---------AKEL------------ 92
               .|:.|  :....::..|:.|        |||||||:|         :||.
Mouse   120 NIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDVKRISKECARKPGKKICRKG 184

  Fly    93 -----------------------DSPRPLPLIVFFFGGGFEKGDPTKELHSPDYF-MMRDVVVVT 133
                                   ||..|.|::|:..||.:.:|  |..|:..... ...:|:|:|
Mouse   185 GPLTKKHTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEG--TGNLYDGSVLASYGNVIVIT 247

  Fly   134 VSYRVGPLGFLSLNDPAVGVPGNAGLKDQLLAMEWIKENAERFNGDPKNVTAFGESAGAASVHYL 198
            |:||:|.|||||..|.|  ..||.||.|.:.|:.|..||...|.|||..:|.||..||.:.|:.|
Mouse   248 VNYRLGVLGFLSTGDQA--AKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLL 310

  Fly   199 MLNPKAE---------GLFHKAILQSGNVLCSWALCTIKNLPHRLAVNLGMESAEHVTDAM-VLD 253
            .|:..:|         |||.:||.|||..|.|||   :...|.:.|..|..:...:|:|.: :::
Mouse   311 TLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWA---VSFQPAKYARILATKVGCNVSDTVELVE 372

  Fly   254 FLQKLPGEKLVRPYLLSAEEHLDDCVFQFGPMVEPYKTEHCALPNHPQELLDKAWGNRIPVLMSG 318
            .|||.|.::||...:..|..|:     .|||::     :...:|:.||.|:::.......:::..
Mouse   373 CLQKKPYKELVDQDVQPARYHI-----AFGPVI-----DGDVIPDDPQILMEQGEFLNYDIMLGV 427

  Fly   319 TSFEGLLMYARVQ-------------MAPYLLTSLKKEPEHMLPLDVKRNLPQALARHLGQRLQE 370
            ...|||.....:.             .....:.:|...||..   ||.|...:.:......|
Mouse   428 NQGEGLKFVENIVDSDDGVSASDFDFAVSNFVDNLYGYPEGK---DVLRETIKFMYTDWADR--- 486

  Fly   371 THFGGNDPSAMSPESLKAYCEYASYKVFWHPILKTLRSRVKSSSASTYLYRFDFDSPTFNHQRLK 435
                 ::|.......|..:.::.     |          |..:.|:..|:. :|.|||:.:....
Mouse   487 -----HNPETRRKTLLALFTDHQ-----W----------VAPAVATADLHS-NFGSPTYFYAFYH 530

  Fly   436 YC-GDKL---RGVAHVDDHSYL----WYGD---FSWKLDKHTPEFLTIERMIDMLTSFARTSNPN 489
            :| .|::   ...||.|:..|:    ..|.   |.....|:  :.:....::...|:||:|.:||
Mouse   531 HCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKN--DVMLSAVVMTYWTNFAKTGDPN 593

  Fly   490 ------CKLIQDQLPRAKE--WKPLNSKSALECLNISENIKMMELPELQKLRVW 535
                  .|.|..:..|.:|  |...:.|..| .|:|....::.|.....|:.:|
Mouse   594 QPVPQDTKFIHTKPNRFEEVAWTRYSQKDQL-YLHIGLKPRVKEHYRANKVNLW 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est3	NP_524267.2	alpha/beta hydrolases	2..535	CDD:473884	158/637 (25%)
Nlgn1	XP_006535478.1	COesterase	52..646	CDD:395084	158/637 (25%)