Protein Alignment alpha-Est3 and cest-1.2

DIOPT Version :10

• Sequence 1: NP_524267.2
• Gene: alpha-Est3 / 40907
• FlyBaseID: FBgn0015571
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_506504.2
• Gene: cest-1.2 / 179914
• WormBaseID: WBGene00011364
• Length: 676
• Species: Caenorhabditis elegans
• Alignment Length: 585
• Identity: 145/585 - (24%)
• Similarity: 239/585 - (40%)
• Gaps: 104/585 - (17%)

  Fly     3 SLQVNTTSGPVLGKQCTGVY----GDEYVSFERIPYAQPPVGHLRFMAPLPVEPWSQPLDCTKPG 63
            |.:|..::|.:.|||....|    ....::|..|||.:||:|.|||..|.|.:.||..|:..|
 Worm    18 STKVQLSTGIIEGKQLNSTYSPFGNQSAIAFLGIPYVEPPIGDLRFRKPRPQKTWSGVLETKK-- 80

  Fly    64 QKPLQFNHYSKQLE--GV-----EDCLYLNVYAKE--LDSPRPLPLIVFFFGGG--FEKGDPTKE 117
            .||...::.:|..:  |:     ||||||||...:  |:: :...:::...|||  ||.......
 Worm    81 FKPACMSNSTKTYKNGGIGGPISEDCLYLNVLTNQYCLEN-KNCSVVIIVHGGGYLFESAATFNH 144

  Fly   118 LHSPDYFMMRD--VVVVTVSYRVGPLGFLSLNDPAVGVPG--NAGLKDQLLAMEWIKENAERFNG 178
            ....:.|:.:|  :||||::||:|..||..||    |..|  |.|:.|.|.|::|::...::|.|
 Worm   145 EILVNNFVGQDRNIVVVTINYRLGIFGFGHLN----GFEGDKNVGIFDTLEAVKWVRREIKQFGG 205

  Fly   179 DPKNVTAFGESAGAASVHYLMLNPKAEGLFHKAILQSGNVLCSWALCTIKNLPHRLAVNLGMES- 242
            :...:|..|.||||..|....::|..:||.|:.|:.||.:.........|.:. .:|..:|..|
 Worm   206 NKDRITLAGHSAGAGVVAAFTISPLTKGLIHQQIVMSGPMTNMSKKSNFKGMT-AMAERVGCHSK 269

  Fly   243 -------AEHVTDAMVLDFLQKLPGEKLVRPYLLSAEEHLDDCVFQFGPMVEPYKTEHCALPNHP 300
                   .||..: .|...|:|.|.::|:...|..    |.:..|.||  ..|...|.  :.::|
 Worm   270 KYGFNKLPEHEVE-QVYSCLRKKPAQELLDAQLWL----LQNSTFYFG--APPVDGEF--ITDYP 325

  Fly   301 QELLDKAWGNRIPVLMSGTSFEGLLMYARVQMAPYLLTSLKKEPEHMLPLDVKRNLPQALARHLG 365
            ..|..:.....|..|:..|:.|       :|...|:..|      :....:.|....:.|...:|
 Worm   326 DNLYSEKSIFSINTLLGTTTRE-------LQDTGYISNS------NYSKFETKETFLKNLCDQIG 377

  Fly   366 -----------QRLQETHFGGNDPSAMSPESLKAYCEYASYKVFWHPILKTLRSRVKSSSASTYL 419
                       .:.|:.:..|:|..::| :.::.|.:..:        |....:| |......|.
 Worm   378 IEIYKESEDFSSKCQKWYINGSDSKSLS-DDMEFYTQAIN--------LADAHAR-KGKKVYMYS 432

  Fly   420 YRFDFDSPTFNHQRLKYCGDKLRGVAHVDDHSYLWYGDFSWKLDKHTPEFLTIERMID-MLTSFA 483
            |.:....|.|.    ||.  |::...|.:|..|    .|........|:...||.:.. |...|.
 Worm   433 YAYSGAGPAFK----KYM--KVKSPHHSEDLIY----TFGTHRGVFAPKDYVIEYIYSGMFADFI 487

  Fly   484 RTSNPNCKLIQDQLPRAKEWKPLNSKSALECLNISENIKMMELPELQK------LRVWESVCQST 542
            ...:|:....|..|...||    |.:..|  ::..:|:.|   |.::|      ...|.:..|.:
 Worm   488 NFEDPSPSTDQPWLQYTKE----NKEYFL--VDFDQNLTM---PGMKKNYYAKAYEFWSTAGQKS 543

  Fly   543  542
             Worm   544  543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est3	NP_524267.2	alpha/beta hydrolases	2..535	CDD:473884	143/576 (25%)
cest-1.2	NP_506504.2	COesterase	18..536	CDD:395084	143/576 (25%)