Protein Alignment alpha-Est3 and cest-5.2

DIOPT Version :10

• Sequence 1: NP_524267.2
• Gene: alpha-Est3 / 40907
• FlyBaseID: FBgn0015571
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_501021.3
• Gene: cest-5.2 / 177428
• WormBaseID: WBGene00015284
• Length: 583
• Species: Caenorhabditis elegans
• Alignment Length: 568
• Identity: 127/568 - (22%)
• Similarity: 209/568 - (36%)
• Gaps: 129/568 - (22%)

  Fly     6 VNTTSGPVLGKQCTGVYGDEYVSFERIPYAQPPVGHLRFMAPLPVEPWSQPLDCTKPGQKPLQFN 70
            :.|:.|.:.|||     ..:|..|.|||:|:||:|.|||..|...|.|:...:.|:.|...:..:
 Worm    24 IKTSLGRLEGKQ-----SGKYQLFRRIPFAKPPIGTLRFQKPESAEKWNGVWNATEYGPACMSNS 83

  Fly    71 HY--SKQLEGVEDCLYLNVYAKE--LDSPRPLPLIVFFFGGG--FEKGDPTKELHSPDYFMMRDV 129
            .:  |.|....||||::|::..:  |.| :...::|:..||.  |:......:....:.|:.:||
 Worm    84 TWTQSPQKWVDEDCLHVNIFTSDKCLKS-KDCAVVVYIHGGEIVFDSAVMFNDTFLLESFVKQDV 147

  Fly   130 VVVTVSYRVGPLGFLSLNDPAVGVPGNAGLKDQLLAMEWIKENAERFNGDPKNVTAFGESAGAAS 194
            ::|..::|:|.....:::|..: .|.|..|.|.:||.|::|.....|.||.:.:|.||.|.|...
 Worm   148 ILVIPAFRLGIFSHFTVHDQNI-APNNLALYDIILAQEFVKSEIHNFGGDIQKITLFGHSYGGTI 211

  Fly   195 VHYLMLNPKAE---GLFHKAILQSGNV--------------LCSWALCTIKNLPHRLAVNLGMES 242
            ...:..:.:..   .||.:.|:.|.|.              :...|.|::   |..||..:....
 Worm   212 ASMMAFSSEINQDLSLFQRIIVMSANQYFDTLEEQIERSDRVVKHAGCSV---PTNLARKMNRSQ 273

  Fly   243 AEHVTDAMVLDFLQKLPGEKLVRPYLLSAEEHLDDCVFQFGPMVEPYKTEHCALPNHPQELLDKA 307
            .|    ..::..||||.|.:     |||.:..|::..:   |.:
 Worm   274 KE----KYMMKCLQKLSGME-----LLSVQRSLEEAGY---PDI--------------------- 305

  Fly   308 WGN---RIPVLMSGTSFEGLLMYARVQMAPYLLTSLKKEPEHMLPLDVKRNLPQALARHLGQRLQ 369
             ||   |.|:....||.|   |....:|.|.|....|.|.:..                     .
 Worm   306 -GNLVLRGPLFPDVTSLE---MLESPKMIPMLAGCTKFESDDE---------------------D 345

  Fly   370 ETHFGGNDPSAMSP-ESLKAYCEYASYKVF--------WHPILKTLRSRV---KSSSASTYLYRF 422
            ||||.|......:| |..:.|.:.....:|        ...|:...:.||   :......|||.|
 Worm   346 ETHFIGKHFGLENPIECDEKYRKDLENGIFDRQNHSDKTQAIMVPTKLRVDQLRKHGVPAYLYEF 410

  Fly   423 DFDSPTFNHQRLKYCGDKLRGVAHVDDHSYLWYGDFSWKLDKHTPEFLTIERMIDMLTSFARTSN 487
            .:....|                |.||..|: .|...::.|::......:.|  :||.:|.:...
 Worm   411 TYPKHAF----------------HTDDLYYI-MGIHPFEKDENEEHLEKVYR--NMLINFIKFGE 456

  Fly   488 PNCKLIQDQLPRAK----EWKPLNSKSALECLNISENIKMMELPELQK 531
            |........|..:.    .|.....:.........|||....|.|:.:
 Worm   457 PGMGFEMSDLNESTYFEIYWNETTGQKPRMRKRFEENITNYWLKEMME 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est3	NP_524267.2	alpha/beta hydrolases	2..535	CDD:473884	127/568 (22%)
cest-5.2	NP_501021.3	alpha/beta hydrolases	21..498	CDD:473884	125/560 (22%)