Protein Alignment alpha-Est3 and cest-25

DIOPT Version :10

• Sequence 1: NP_524267.2
• Gene: alpha-Est3 / 40907
• FlyBaseID: FBgn0015571
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_497609.1
• Gene: cest-25 / 175390
• WormBaseID: WBGene00022178
• Length: 550
• Species: Caenorhabditis elegans
• Alignment Length: 549
• Identity: 157/549 - (28%)
• Similarity: 242/549 - (44%)
• Gaps: 93/549 - (16%)

  Fly     3 SLQVNTTSGPVLGKQCTGVYGDEYVSFERIPYAQPPVGHLRFMAPLPVEPWSQPLDCTKPGQKPL 67
            |.||.|:.||:.|::.......:..:|:.||||.||:|:|||..|.|.|.|::..:....|.:.:
 Worm    16 SRQVLTSYGPIEGRRLIHEGEKQVDAFQGIPYAAPPIGNLRFALPQPHEKWTEVRETKSFGARGI 80

  Fly    68 QFNHY--SKQLEGVEDCLYLNVYAKELDSPR---PLPLIVFFFGGGFEKGDPTK--ELHSPDYFM 125
            |.:|.  .|.....||.|.||::. .:.:|:   ..|:|::..||||......|  ::....:.:
 Worm    81 QKDHVLSPKTSPQSEDNLTLNIFT-PVWTPKNETGFPVILYIHGGGFVSDSAHKYGDMSICQHLV 144

  Fly   126 MRDVVVVTVSYRVGPLGFLSLNDPAVGVPGNAGLKDQLLAMEWIKENAERFNGDPKNVTAFGESA 190
            .:||||||:.||:|.|||.:..|.:  :|.|..|.|.:.|::|:|||...|||||.|:|..|:||
 Worm   145 TKDVVVVTIQYRLGFLGFWTTGDSS--IPDNVALHDMVFALKWVKENIGLFNGDPNNITLMGQSA 207

  Fly   191 GAASVHYLMLNPKAEGLFHKAILQSGNVLCSWA-----LCTIKNLPHRLAVNLGMESAEHVTDAM 250
            |.|||.:|.::|.:..||.|.|...||..||||     |...:|....:.|..||.:.:.|
 Worm   208 GGASVDFLSISPVSRDLFQKVIPMGGNASCSWAIHPRPLNACRNRAQEIGVFDGMNTLDWV---- 268

  Fly   251 VLDFLQKLPGEKLVRPYLLSAEEHLDDCVFQFGPMVEPYKTEHCALPNHPQELLDKAWGNRIPVL 315
              :.|::||.:|......:.|.:...|.....||     |.::..:|....||..:|  ...|.|
 Worm   269 --EKLRELPADKFASALNMEAVDTKTDPELLIGP-----KYDNLFIPRPVMELRKEA--PMKPRL 324

  Fly   316 MSGTSFEGLLMYARVQMAPYLLTSLKKEPEHMLPLDVKRNLPQAL----ARHLGQR-LQETHFGG 375
            :.....|||:      .|.:.|.:  |.|.|.:..||...|.:.|    ||...:: |::....|
 Worm   325 LGCAKSEGLV------FAFFGLNT--KHPLHAVQQDVSAILSEKLFPLKARDYQEKALEKLIEIG 381

  Fly   376 NDPSAMSPESLKAYCEYASYKVFWHPILKTLRS-------------RVKSSSASTYLYRFDFDSP 427
            .|.|                |..|...:..|:.             .|..:..||.:|.:.||
 Worm   382 TDHS----------------KEEWQRAMVDLKGDSFLNVGIQQNVLDVLETQPSTPIYMYSFD-- 428

  Fly   428 TFNHQRLKYCGDKLRGV----------AHVDDHSYLWYGDFSWKLDKHTPEFLTIERMIDMLTSF 482
                    ||..|..|:          .|..|.||:.........|.:..::..||....:.|:|
 Worm   429 --------YCNPKAYGIMGFKLPFKDATHCTDISYVVGNHIVNSFDFNEEDYKMIEITTRLWTNF 485

  Fly   483 ARTSNPNCKLIQDQLPRAKE-WKPLNSKS 510
            |:..|||.:  .|.:...:| |:|...:|
 Worm   486 AKYGNPNGE--GDDVAHLEEKWEPATIES 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est3	NP_524267.2	alpha/beta hydrolases	2..535	CDD:473884	157/549 (29%)
cest-25	NP_497609.1	COesterase	15..536	CDD:395084	157/549 (29%)