Protein Alignment alpha-Est3 and Ces3b

DIOPT Version :10

• Sequence 1: NP_524267.2
• Gene: alpha-Est3 / 40907
• FlyBaseID: FBgn0015571
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_653094.2
• Gene: Ces3b / 13909
• MGIID: 3644960
• Length: 571
• Species: Mus musculus
• Alignment Length: 577
• Identity: 164/577 - (28%)
• Similarity: 250/577 - (43%)
• Gaps: 102/577 - (17%)

  Fly     5 QVNTTSGPVLGKQCTGVYGDEYVS-FERIPYAQPPVGHLRFMAPLPVEPWS-------QPLDCTK 61
            :|:|..|.|.|:|......|..|: |..||:||.|||.|||.||||.:||.       .|..|.:
Mouse    38 EVDTPLGRVRGRQVGVKDTDRMVNVFLGIPFAQAPVGPLRFSAPLPPQPWEGVRDASINPPMCLQ 102

  Fly    62 PGQKPLQ----FNHYSKQLEGVEDCLYLNVYA-KELDSPRPLPLIVFFFGGGFEKGDPTKELHSP 121
            ..:|.:.    .|...|.....||||.||:|: .|:.:....|::|:..||....|..|.:..|.
Mouse   103 DVEKMINSRFGLNEKIKIFPISEDCLTLNIYSPTEITAGDKRPVMVWIHGGSLLVGSSTSQDGSA 167

  Fly   122 DYFMMRDVVVVTVSYRVGPLGFLSLNDPAVGVPGNAGLKDQLLAMEWIKENAERFNGDPKNVTAF 186
             .....|||||||.||:|..||||..|.  .:|||.|..|.:.|:.|::.|...|.|||..||.|
Mouse   168 -LAAYGDVVVVTVQYRLGIFGFLSTGDK--HMPGNRGFLDVVAALRWVQGNIAPFGGDPNCVTIF 229

  Fly   187 GESAGAASVHYLMLNPKAEGLFHKAILQSGNVLCSWALCTIKNLP--HRLAVNLGMESAEHVTDA 249
            |.|||...|..|.|:|.:.||||:||.||| ::.:..:..:|..|  ...|.::...||   :.|
Mouse   230 GNSAGGMIVSSLFLSPISAGLFHRAISQSG-IVTTIMMEDMKPWPEAQNFANSVACGSA---SPA 290

  Fly   250 MVLDFLQKLPGEKLVRPYLLSAEEHLDDCVFQFGPMVEPYKTEHCALPNHPQELLDKAWGNRIPV 314
            .::..|.:..|:.|::...::....::|..|                |..|::||.......:|.
Mouse   291 ELVQCLLQKEGKDLIKQKNVNISYIVNDSFF----------------PQRPEKLLADQQFPTVPY 339

  Fly   315 LMSGTSFE-GLLMYARVQMAPYLLTSLKKEPEHMLP---LDVKRNL-------PQALARHLGQRL 368
            |:..|:.| |.|:...:.:...|        ||:..   |::.|..       |:.:...:.:.|
Mouse   340 LLGVTNHEFGWLLLKSLNILDKL--------EHLSREDLLEISRPFLAIMEVPPEIMPTVIDEYL 396

  Fly   369 QETHFGGNDPSAMSPESLKAYCEYASYKVFWHPILKTLRSRVKSSSASTYLYRFDFDSPTFNHQR 433
            .    .|:|.||    :..|:.|......|..|.| .....::.:....:||.|.....:|  .:
Mouse   397 D----NGSDQSA----TRYAFQELLGDISFIIPTL-NFSKYLRDAGCPVFLYEFQHTPSSF--AK 450

  Fly   434 LKYCGDKLRGVAHVDDHSYLWYGDFSWKLDKHT----PEFLTIERMIDML-----TSFARTSNPN 489
            .|....|   ..|..::|:::.|.|  ..|:.:    ||....|:.:.:.     :.||||.|||
Mouse   451 FKPAWVK---ADHASENSFVFGGPF--LTDESSLLAFPEATEEEKQLSLTMMAQWSQFARTGNPN 510

  Fly   490 CKLIQDQLPRAKEWKPLNS-KSALEC-LNISENIKMME---------LPELQKLRVW 535
            .|    .||   .|..||. :..||. |.....:|:.:         ||  :|::.|
Mouse   511 GK----GLP---PWPQLNQLEQYLEIGLESRTGVKLKKGRLQFWTETLP--RKIQEW 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est3	NP_524267.2	alpha/beta hydrolases	2..535	CDD:473884	163/575 (28%)
Ces3b	NP_653094.2	COesterase	36..547	CDD:395084	160/562 (28%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571