DRSC - DRSC Integrative Ortholog Prediction Tool

DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Est3 and AADACL3

DIOPT Version :10

Sequence 1:	NP_524267.2	Gene:	alpha-Est3 / 40907	FlyBaseID:	FBgn0015571	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001096640.2	Gene:	AADACL3 / 126767	HGNCID:	32037	Length:	407	Species:	Homo sapiens

Alignment Length:	43	Identity:	16/43 - (37%)
Similarity:	22/43 - (51%)	Gaps:	10/43 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 KPQYAHGLGEYL------GQS-SQKMNVITSTVV--GEKREDC 95
            |.|..|. ||.|      |:: |||.|::|...:  |||..:|
Human    61 KHQSTHS-GEKLFECSDCGKAFSQKENLLTHQKIHTGEKPFEC 102

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est3	NP_524267.2	alpha/beta hydrolases	2..535	CDD:473884	16/43 (37%)
AADACL3	NP_001096640.2	Abhydrolase_3	115..378	CDD:400284
AADACL3	NP_001096640.2	Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250\|UniProtKB:Q5NUF3	119..121
Blue background indicates that the domain is not in the aligned region.

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