Protein Alignment alpha-Est4 and CES2

DIOPT Version :9

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_001352334.1
• Gene: CES2 / 8824
• HGNCID: 1864
• Length: 559
• Species: Homo sapiens
• Alignment Length: 588
• Identity: 164/588 - (27%)
• Similarity: 240/588 - (40%)
• Gaps: 145/588 - (24%)

  Fly     7 EDAPVVQTTH-GKVRGIL--LKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKP 68
            :.|..::||| |:|.|.|  :|.. :.....|.|||:|.||||.|||..|...:.|.|:||.:..
Human    28 DSASPIRTTHTGQVLGSLVHVKGA-NAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTH 91

  Fly    69 LSKCLQVSTLTKEVEG---------------SEDCLYLNI--SVKTLNGDPMPVMVYIHGGAFKG 116
            .:.|||..|   .||.               |||||||:|  ...:..|..:||||:|||||...
Human    92 PAMCLQDLT---AVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVF 153

  Fly   117 G-----DSSRRAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRA 176
            |     |.|..|      ..||||.:.|.:|||.|||.|..|.  ...||.|..|.:.||||::.
Human   154 GMASLYDGSMLA------ALENVVVVIIQYRLGVLGFFSTGDK--HATGNWGYLDQVAALRWVQQ 210

  Fly   177 NAANFNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNRLPQMEYRLAKHLG 241
            |.|:|.|:|:|:||||.|:|..:|..|:.||.|:||||.||:.:|.::    ||.:....|..:.
Human   211 NIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVAL----LPGLIASSADVIS 271

  Fly   242 ------YEGDNVDSQVLEFLLKADPALIVSADFFTPLEKRQGHNMPFK--PSIESYSTPNAVLLA 298
                  ...|.|||:.|...|:....           |:....|.|||  |.:    .....|..
Human   272 TVVANLSACDQVDSEALVGCLRGKSK-----------EEILAINKPFKMIPGV----VDGVFLPR 321

  Fly   299 EPIDLQRTTWSNRIPIILGANSGEGMSIFSFVKMNPSWLKEFQCNPER----------------V 347
            .|.:|..:.....:|.|:|.|:.|      |..:.|..::.:....|.                :
Human   322 HPQELLASADFQPVPSIVGVNNNE------FGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLM 380

  Fly   348 LPWT----LRNRC--DPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGFVHAMDRLIQS 406
            ||.|    ||...  |.|..:.|         :|...|:..|.            :..:..|..:
Human   381 LPPTFGDLLREEYIGDNGDPQTL---------QAQFQEMMADS------------MFVIPALQVA 424

  Fly   407 RLTYGQAPTYLYRFDFDSPDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATF------KLDKSRP 465
            .....:||.|.|.|..........|...|..:     |.|||.::|:   :|      |..:...
Human   425 HFQCSRAPVYFYEFQHQPSWLKNIRPPHMKAD-----HGDELPFVFR---SFFGGNYIKFTEEEE 481

  Fly   466 EFTAIRRLVAMFVQFAATSDPNAPLTKSLVDWKPVTRFGKRMVLNI---------SEELKF---- 517
            :.:  |:::..:..||...:||.   :.|..|....:..:.:.||:         :..|:|
Human   482 QLS--RKMMKYWANFARNGNPNG---EGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKA 541

  Fly   518 IPQ 520
            :||
Human   542 LPQ 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	164/588 (28%)
		Aes	<104..>219	CDD:223730	57/119 (48%)
CES2	NP_001352334.1	COesterase	30..538	CDD:306613	161/578 (28%)
		Prevents secretion from ER. /evidence=ECO:0000255	556..559

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142694
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.790