DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and Ces2g

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_932116.2	Gene:	Ces2g / 72361	MGIID:	1919611	Length:	560	Species:	Mus musculus

Alignment Length:	597	Identity:	171/597 - (28%)
Similarity:	257/597 - (43%)	Gaps:	152/597 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DYNEDAPVVQTTHGKVRGILLKSLYDEQ--FYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCS 66
            |..|.:|:..|..|:|:|.|: .:.|.:  .:.|.|||:|.||:|.|||..|...:||.|:||.:
Mouse    28 DSPETSPIRSTHSGQVQGRLI-HVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGT 91

  Fly    67 KPLSKCLQVSTLTKE-----------VEGSEDCLYLNI--SVKTLNGDPMPVMVYIHGGAFKGGD 118
            ...:.|.|..|:..|           |..|||||||||  ......|..:||||:|||||...|.
Mouse    92 SQPAICPQNVTMNMEGLKELKLTLPPVSMSEDCLYLNIYTPAHAQEGSNLPVMVWIHGGALTVGM 156

  Fly   119 SSRRAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNG 183
            :|... |......|:||.::|.:|||.|||.|..|.  ...||.|..|.:.||||::.|.|:|.|
Mouse   157 ASMYD-GSVLAATEDVVVVAIQYRLGVLGFFSTGDE--HARGNWGFLDQVAALRWVQQNIAHFGG 218

  Fly   184 DPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNRLP-------QMEYR-LAKHL 240
            :|:|:||||.|:|.::|...:.||.|:|||||||:.:|.::    ||       ::.|: :||..
Mouse   219 NPDRVTIFGESAGGISVSSHVVSPMSKGLFHRAIMESGVAL----LPGTIFSFSEVVYQTVAKLS 279

  Fly   241 GYEGDNVDSQVL----------------------------EFLLKADPALIVSADFFTPLEKRQG 277
            |.|.  :||:.|                            |||.|....|:.||||
Mouse   280 GCEA--MDSEALVRCLRGKSEEEILAISKNFQMIPGVVDGEFLPKHPQELLASADF--------- 333

  Fly   278 HNMPFKPSIESYSTPNAVLLAEPIDLQRTTWSNRIPIILGANSGEGMSIFSFVKMN-PSWLKEFQ 341
            |.:   |||..::.            ....|.  :|.::|:.    .:|....:.| .:.||:
Mouse   334 HPV---PSIIGFNN------------DEYGWI--VPKVIGST----QTIKGITRENLQAVLKD-- 375

  Fly   342 CNPERVLPWTLRNRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFT---HGFVHAMDRL 403
            ..|:.:||            .:....|:..:.|      .::....|...||   ..|:..:..|
Mouse   376 TAPQMMLP------------PECSDLLMEEYME------DIEDPKTLQIQFTEMMEDFMFVIPSL 422

  Fly   404 IQSRLTYGQAPTYLYRFDFDSPDFNFYRIRFMGKEQR----GVGHVDELGYIFKLPATF----KL 460
            ..:......||.|.|.|...|        .|: |:.|    ...|.||:.::|   .:|    ||
Mouse   423 QVAYFQRSHAPVYFYEFQHQS--------SFL-KDVRPPHVNADHGDEVPFVF---GSFFWGMKL 475

  Fly   461 DKSRPEFTAIRRLVAMFVQFAATSDPNAPLTKSLVDWKPVTRFGKRMVLNISEELKFIPQP---- 521
            :.:..|....||::..:..||...:||   ::||..|.......:.:.|||        ||
Mouse   476 NLTEEEKLLNRRMMKYWANFARHGNPN---SESLPYWPVFDHDEQYLQLNI--------QPAVGQ 529

  Fly   522 --EMPKLKFFDR 531
              :..||:|:.:
Mouse   530 FQKARKLQFWTK 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	169/590 (29%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	55/114 (48%)
Ces2g	NP_932116.2	COesterase	31..539	CDD:278561	169/590 (29%)
Ces2g	NP_932116.2	Aes	72..>337	CDD:223730	100/285 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832740
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740