DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and Ces2f

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001073334.2	Gene:	Ces2f / 71903	MGIID:	1919153	Length:	561	Species:	Mus musculus

Alignment Length:	590	Identity:	164/590 - (27%)
Similarity:	247/590 - (41%)	Gaps:	131/590 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DYNEDAPVVQTTHGKVRGILLKSLYDEQFYA--FDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCS 66
            |.:|.:|:..|..|:|||..: .|.|.:..|  |.|||:|.||:|.|||..|...:||.|:||.:
Mouse    28 DSSEASPIRNTHTGQVRGKFV-HLTDIKAGAHNFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGT 91

  Fly    67 KPLSKCLQVSTLTKEVEG-------------SEDCLYLNI--SVKTLNGDPMPVMVYIHGGAFKG 116
            ...:.|||...:. .:||             |||||||||  ......|..:||||::|||....
Mouse    92 SQPAMCLQNDDIV-NLEGLKIIKMILPPFSMSEDCLYLNIYTPAHAQEGSNLPVMVWLHGGGLVA 155

  Fly   117 GDSSRRAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANF 181
            |.:|... |......|:||.:...:|||..||.|..|.  :..||.|..|...||.|::.|.|||
Mouse   156 GMASMYD-GSVLAATEDVVVVVTQYRLGIPGFYSTGDE--QARGNWGFLDQTAALHWVQQNIANF 217

  Fly   182 NGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSM---ELNRLPQMEY-RLAKHLGY 242
            .|:|:.:|:||.|:|..:|...:.||.|:|||||||:.:|.::   .:...|:|.: ::|...|.
Mouse   218 GGNPDSVTLFGQSAGGTSVSFHVLSPVSQGLFHRAIMESGVALLPTIIPDSPEMIFTKVANLSGC 282

  Fly   243 EGDNVDSQVLEFLLKADPALIVSADFFTPLEKRQGHNMPFKPSIESYSTPNAVLLAEPIDLQRTT 307
            |..|.::.|.....|::..::..:..|.           |.|::    .....|...|..|..:.
Mouse   283 ETSNSEALVRCLRGKSEAEILAMSKAFR-----------FMPAV----VDGKFLPRHPKKLLASA 332

  Fly   308 WSNRIPIILGANSGE-GM---SIFSFV----KMNPSWLKEF------------QCNP---ERVL- 348
            ..:.:|.|:|.|:.| |.   .||.|.    |:|.:.||..            :|..   |..|
Mouse   333 DFHPVPSIIGVNNDEYGWIIPKIFKFSQTIRKINRNNLKAIMKITTEQMMLPSECGDLLIEEYLR 397

  Fly   349 ----PWTLRNRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGFVHAMDRLIQSRLT 409
                ||||:.:.    |..:|..||                             .:..|..:|..
Mouse   398 DTEDPWTLQMQF----REMIGDFLI-----------------------------IIPALQVARFQ 429

  Fly   410 YGQAPTYLYRFDFDSPDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATF----KLDKSRPEFTAI 470
            ...||.|.|.|...|....::|...:..:     |.|||..||   .:|    |...:..|....
Mouse   430 RSHAPVYFYEFQHRSSLLKYFRPWHVKAD-----HGDELYLIF---GSFFWGLKFSFTAEEKLLS 486

  Fly   471 RRLVAMFVQFAATSDPNAPLTKSLVDWKPVTRFGKRMVLNISEEL-------------KFIPQPE 522
            |:::..:..||...:||   ::.|..|....:....:.|:|...:             |.:|| :
Mouse   487 RKMMKYWANFARYGNPN---SEDLPYWPASNQDDLYLQLDIHPSVGHALKARRLPFWTKTLPQ-K 547

  Fly   523 MPKLK 527
            |.:||
Mouse   548 MLELK 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	163/587 (28%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	49/114 (43%)
Ces2f	NP_001073334.2	COesterase	32..540	CDD:395084	156/571 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832774
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740