DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Est4 and TG

DIOPT Version :9

Sequence 1:NP_524266.1 Gene:alpha-Est4 / 40906 FlyBaseID:FBgn0015572 Length:541 Species:Drosophila melanogaster
Sequence 2:NP_003226.4 Gene:TG / 7038 HGNCID:11764 Length:2768 Species:Homo sapiens


Alignment Length:521 Identity:128/521 - (24%)
Similarity:198/521 - (38%) Gaps:131/521 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 YNEDAPVVQ-TTHGKVRG----ILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRD 64
            |....|.|. :|||::.|    |.:.:.: :|...|.|:|||.|||...||:.|..|. |.|..|
Human  2194 YEASVPSVPISTHGRLLGRSQAIQVGTSW-KQVDQFLGVPYAAPPLAERRFQAPEPLN-WTGSWD 2256

  Fly    65 CSKPLSKCLQVSTLTKEVEG-SEDCLYLNISVKTLNGDPMPVMVYIHGGAFKGGDSSRRAW---- 124
            .|||.:.|.|..|.|....| ||||||||:.:.........|:|:.|....:   .....|    
Human  2257 ASKPRASCWQPGTRTSTSPGVSEDCLYLNVFIPQNVAPNASVLVFFHNTMDR---EESEGWPAID 2318

  Fly   125 GPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERIT 189
            |.......|::.::..:|:|..||||....  ||.||.||.|.:.||.|::.:...|.|||.|::
Human  2319 GSFLAAVGNLIVVTASYRVGVFGFLSSGSG--EVSGNWGLLDQVAALTWVQTHIRGFGGDPRRVS 2381

  Fly   190 IFGHSSGS--MTVQLLLASPQSEGLFHRAILLAGFSM------ELNRLPQMEYRLAKHLGYEGDN 246
            :.....|:  .::.||.|...:..||.||:|:.|.::      ...|..|....|||.:.....:
Human  2382 LAADRGGADVASIHLLTARATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALAKEVSCPMSS 2446

  Fly   247 VDSQVLEFLLKADPALIVSADFFTPLEKRQGHNMPFK---PSIESYSTPNAVLLAEP--IDLQRT 306
              ||.:...|:..||.::: |..|.|....|   ||.   |.|:.:      .|.||  ..|:|:
Human  2447 --SQEVVSCLRQKPANVLN-DAQTKLLAVSG---PFHYWGPVIDGH------FLREPPARALKRS 2499

  Fly   307 TWSNRIPIILGANSGEGM--------------------SIFSFVKMNPSWLKEFQCNPERVLPW- 350
            .|. .:.:::|::..:|:                    :.|.....|....::.....|....| 
Human  2500 LWV-EVDLLIGSSQDDGLINRAKAVKQFEESRGRTSSKTAFYQALQNSLGGEDSDARVEAAATWY 2563

  Fly   351 -TLRNRCD---------------------------PGQRRQLGQALIHHFCEAHGH---ELTVDH 384
             :|.:..|                           ...:|..|...::|..|.:||   ||..|.
Human  2564 YSLEHSTDDYASFSRALENATRDYFIICPIIDMASAWAKRARGNVFMYHAPENYGHGSLELLADV 2628

  Fly   385 TNGL-----------------------VELFTHGFVHAMDRLIQSRLTYGQAPTYLYRFDFDSPD 426
            ...|                       ::.|:| |:.:.:            |.|.|.|....|.
Human  2629 QFALGLPFYPAYEGQFSLEEKSLSLKIMQYFSH-FIRSGN------------PNYPYEFSRKVPT 2680

  Fly   427 F 427
            |
Human  2681 F 2681

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-Est4NP_524266.1 Abhydrolase 7..529 CDD:304388 127/519 (24%)
Aes <104..>219 CDD:223730 35/120 (29%)
TGNP_003226.4 TY 33..92 CDD:238114
TY 95..160 CDD:238114
TY 300..358 CDD:238114
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..545
Thyroglobulin_1 599..658 CDD:395039
Thyroglobulin_1 662..724 CDD:395039
TY 729..>776 CDD:412186
TY <892..922 CDD:412186
TY 1004..1073 CDD:238114
TY 1077..1145 CDD:238114
TY 1149..1210 CDD:238114
Type II. /evidence=ECO:0000269|PubMed:8797845 1456..1469
Ephrin_rec_like 1465..1510 CDD:400166
Type II. /evidence=ECO:0000269|PubMed:8797845 1470..1486
Type II. /evidence=ECO:0000269|PubMed:8797845 1487..1503
TY 1520..1567 CDD:214561
Type IIIA. /evidence=ECO:0000269|PubMed:8797845 1603..1723
Type IIIB. /evidence=ECO:0000269|PubMed:8797845 1724..1892
Type IIIA. /evidence=ECO:0000269|PubMed:8797845 1893..1995
Type IIIB. /evidence=ECO:0000269|PubMed:8797845 1996..2129
Type IIIA. /evidence=ECO:0000269|PubMed:8797845 2130..2187
Cholinesterase-like (ChEL). /evidence=ECO:0000250|UniProtKB:O08710 2188..2768 128/521 (25%)
COesterase 2197..2718 CDD:395084 127/518 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2727..2768
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142807
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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