DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est4 and Ces1a

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001177304.1	Gene:	Ces1a / 679817	RGDID:	1583671	Length:	563	Species:	Rattus norvegicus

Alignment Length:	568	Identity:	158/568 - (27%)
Similarity:	241/568 - (42%)	Gaps:	83/568 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDDYNEDAPVVQTTHGKVRG--ILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIR 63
            |:..:....|||.|..|||.|  |.|:. :.:....|.|:|:|.||||:|||..|...:.|..::
  Rat    15 MAFGHPSSPPVVDTLQGKVLGKYISLEG-FTQPVAVFLGVPFAKPPLGSLRFAPPQPAESWSFVK 78

  Fly    64 DCSKPLSKCLQVS--------TLTKEVEG-----SEDCLYLNISVKT--LNGDPMPVMVYIHGGA 113
            :.:.....|.|::        ..|.::|.     |||||||||...|  .:.|.:||||::|||.
  Rat    79 NATSYPPMCSQITGVGPVLSEVFTNQLENVPLEYSEDCLYLNIYSPTDLTSKDRLPVMVWVHGGG 143

  Fly   114 FKGGDSSRRAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANA 178
            ...|.:|... |......|.||.:.|.:|||..||||..|....  ||.|..|.:.||:|::.|.
  Rat   144 LLSGGASTFD-GLALSTHEKVVVVVIQYRLGIWGFLSTGDEHSR--GNWGHFDQVAALQWVQNNI 205

  Fly   179 ANFNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSM------ELNRLPQMEYRLA 237
            .||.|||..:|:||.|:|..:|.:|:.||.::.||||||..:|.::      |..||...:..:|
  Rat   206 VNFGGDPNSVTLFGESAGGESVSVLVLSPLTKNLFHRAISESGVALTPCLFRENTRLAAEQVAIA 270

  Fly   238 KHLGYEGDNVDSQVLEFLL-KADPALIVSA---DFFT-PLEKRQGHNMPFKPS-IESYSTPNAVL 296
            ...   .....:.::..|. |.:..|:.:.   .||. .|......:.||..: |:....|.|
  Rat   271 TGC---AATTSADIVRCLREKTEEELLATTLKMKFFALDLHGDPRESYPFLTTVIDGVLLPKA-- 330

  Fly   297 LAEPIDLQRTTWSNRIPIILGANSGE-GMSIFSFVKMNPSWLKEFQCNPERVLPW------TLRN 354
               |.::......|.:|.|:|.|..| |..|.:.:....|..|..|.....:| |      .:..
  Rat   331 ---PEEILSEKNFNTVPYIVGINKQEFGWFIPTMMGYPLSESKLDQKTATSLL-WKSYPLTNISK 391

  Fly   355 RCDP-GQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGFVHAMDRLIQSRLTY---GQAPT 415
            ...| ...:.||.:    .|.....:|.:|....:  ||      |:..:|.:|  |   .:|.|
  Rat   392 ELTPVATEKYLGGS----DCPDKKKDLFLDMMGDV--LF------AVPSVIVAR--YHRDARATT 442

  Fly   416 YLYRFDFDSPDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQF 480
            |:|.|.: .|.|    :..|..:.....|.||:..::..| ..|...|..|......::..:..|
  Rat   443 YVYEFKY-HPSF----VSDMRPKTVIADHGDEVYSVWGTP-FLKEGASEEEINLSTMMMKFWGNF 501

  Fly   481 AATSDPNAPLTKSLVDWKPVTRFGKRMVLNISEELKFIPQPEMPKLKF 528
            |...:||.   :.|..|.....  |...|.|...::     :..|||:
  Rat   502 ARNGNPNG---EGLPHWPEYDE--KESYLQIGTTIQ-----QAQKLKY 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	157/562 (28%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	50/114 (44%)
Ces1a	NP_001177304.1	COesterase	24..545	CDD:278561	157/559 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336528
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750