Protein Alignment alpha-Est4 and Ces2b

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_001094469.1
• Gene: Ces2b / 679149
• RGDID: 1591847
• Length: 561
• Species: Rattus norvegicus
• Alignment Length: 552
• Identity: 159/552 - (28%)
• Similarity: 235/552 - (42%)
• Gaps: 128/552 - (23%)

  Fly     7 EDAPVVQTTHGKVRGILLKSLYDEQ--FYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPL 69
            |.:|:..|..|:||| .|..:.|.:  .:.|.|||:|.||:|.|||..|...:||.|:||.:...
  Rat    31 ESSPIRNTHIGQVRG-KLDHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSQP 94

  Fly    70 SKCLQ-VSTLTKE-----------VEGSEDCLYLNI--SVKTLNGDPMPVMVYIHGGAFKGGDSS 120
            :.||| :..:..|           |..|||||||||  ......|..:||||:||||....|.:|
  Rat    95 AMCLQNLDVINAEGLKEMKLKLPPVSMSEDCLYLNIYAPAHAHEGSNLPVMVWIHGGGLMTGMAS 159

  Fly   121 RRAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDP 185
            ... |....:.|::|.::|.:|||.|||.|..|.  ...||.|..|.:.||||::.|.|:|.|:|
  Rat   160 MYD-GSLLTVNEDLVVVTIQYRLGVLGFFSTGDE--HARGNWGYLDQVAALRWVQQNIAHFGGNP 221

  Fly   186 ERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNRLPQM--------EYRLAKHLGY 242
            :|:||||.|:|...|...:.||.|:||||.||:.:|.::    ||.:        ...:||..|.
  Rat   222 DRVTIFGESAGGTCVSTHVVSPMSQGLFHGAIMESGVAL----LPYLIADTSEMFSTMVAKVSGC 282

  Fly   243 EGDNVDSQVLEFLLKAD---------------PALIVSADFFTPLEKRQGHNMPFKPSIESYSTP 292
            |.  :||:.|...|:|.               || :|..:|.....|....:..|:|
  Rat   283 EA--MDSEALVHCLRAKSEAEILAINKVVQMVPA-VVDGEFLPRHPKELLASEDFRP-------- 336

  Fly   293 NAVLLAEPIDLQRTTWSNRIPIILGANSGEGMSIFSFVKMNPSWLKEF-QCNPERVLPWTLRNRC 356
                               :|.|:|.|:.|.......|......:||. :.|.:.:|
  Rat   337 -------------------VPSIIGVNNDEYGWTIPLVMGTTQMIKELSRENLQAIL-------- 374

  Fly   357 DPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVE-------LFT---HGFVHAMDRLIQSRLTYG 411
                ::...|.::...|.    :|.::...|.:|       .||   ..|:..:..|..:.....
  Rat   375 ----KKTTAQLMLPLECS----DLLMEEYMGDIEDPKTLQAQFTELMEDFMFVIPALQVAHFQCS 431

  Fly   412 QAPTYLYRFDFDSPDFNFYRIRFMGKEQR----GVGHVDEL----GYIFKLPATFKLDKSRPEFT 468
            .||.|.|.|.        ::|.|: |:.|    ...|.||:    ||.|   ...|.|.:..|..
  Rat   432 HAPVYFYEFQ--------HQITFL-KDIRPPHVKADHGDEIPFVFGYFF---WDMKTDFTEEEKL 484

  Fly   469 AIRRLVAMFVQFAATSDPNAPLTKSLVDWKPV 500
            ..||::..:..||...:||   ::.|..| ||
  Rat   485 LSRRMMKYWANFARHGNPN---SEGLSYW-PV 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	158/551 (29%)
Ces2b	NP_001094469.1	COesterase	32..540	CDD:395084	158/551 (29%)