Protein Alignment alpha-Est4 and Aadac

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_075872.1
• Gene: Aadac / 67758
• MGIID: 1915008
• Length: 398
• Species: Mus musculus
• Alignment Length: 353
• Identity: 65/353 - (18%)
• Similarity: 117/353 - (33%)
• Gaps: 123/353 - (34%)

  Fly    17 GKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCS--------------- 66
            ||...:|: |:....:|.:..:|.|:.             :||..:.:.:
Mouse     2 GKTISLLI-SVVLVAYYLYIPLPDAIE-------------EPWKVVWETAFVKIGTDLASFGELL 52

  Fly    67 --KPLSKCLQVSTLTKEVEGSEDCLYLNISVKTLNGDPMPVMV---------------YIHGGAF 114
              ....:.:|:....:||..:.|   .:::|.....|.:||.:               |||||.:
Mouse    53 GISHFMETIQLLMSFQEVPPTSD---EHVTVMETAFDSVPVRIYIPKRKSMALRRGLFYIHGGGW 114

  Fly   115 KGGDSSR------RAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRW 173
            ..|.::.      ..|...   |.:.|.:|..:.|.|.......           .:||..:|||
Mouse   115 CLGSAAHFSYDTLSRWTAH---KLDAVVVSTDYGLAPKHHFPRQ-----------FEDVYRSLRW 165

  Fly   174 IRAN--AANFNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNRLPQMEYRL 236
            ....  ...:..||.|:.:.|.|:|..                   |.|..:.:|.:.|.::.:|
Mouse   166 FLQEDVLEKYGVDPRRVGVSGDSAGGN-------------------LAAAVTQQLIQDPDVKIKL 211

  Fly   237 AKHLGYEGDNVDSQVLEFLLKADPALIVSADFFTPLEKRQGHNMPFKPSI------ESYST---- 291
                       ..|.|.:     ||| .:.|...|.::...|......|:      |.::|
Mouse   212 -----------KVQALIY-----PAL-QALDTNVPSQQEGSHFPVLTRSLMVRFWSEYFTTDRGL 259

  Fly   292 PNAVLLAE--PID----LQRTTWSNRIP 313
            ..|:||.:  |::    ||...||:.:|
Mouse   260 EKAMLLNQHVPMESSHLLQFVNWSSLLP 287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	65/353 (18%)
Aadac	NP_075872.1	Abhydrolase_3	106..356	CDD:400284	48/232 (21%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	110..112		1/1 (100%)