DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Est4 and Bche

DIOPT Version :10

Sequence 1:NP_524266.1 Gene:alpha-Est4 / 40906 FlyBaseID:FBgn0015572 Length:541 Species:Drosophila melanogaster
Sequence 2:NP_075231.1 Gene:Bche / 65036 RGDID:619996 Length:597 Species:Rattus norvegicus


Alignment Length:579 Identity:167/579 - (28%)
Similarity:268/579 - (46%) Gaps:89/579 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 YNEDAPVVQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPL 69
            :.|:..::.|..|:|||:.:..| .....||.|||||.||||:||||:|..|..|..:.:.:|..
  Rat    22 HTEEDVIITTKTGRVRGLSMPIL-GGTVTAFLGIPYAQPPLGSLRFKKPQPLNKWPDVYNATKYA 85

  Fly    70 SKCLQ-VSTLTKEVEG----------SEDCLYLNISVKTLNGDPMP------VMVYIHGGAFKGG 117
            :.|.| :.......:|          ||||||||:.:      |:|      |||:::||.|:.|
  Rat    86 NSCYQNIDQAFPGFQGSEMWNPNTNLSEDCLYLNVWI------PVPKPKNATVMVWVYGGGFQTG 144

  Fly   118 DSSRRAWGPDYFMK-ENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANF 181
            .||...:...:..: |.|:.:|:.:|:|.||||:. ..:.|.|||.||.|..|||:||:.|.|.|
  Rat   145 TSSLPVYDGKFLTRVERVIVVSMNYRVGALGFLAF-PGNSEAPGNMGLFDQQLALQWIQRNIAAF 208

  Fly   182 NGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNRLPQME------YRLAKHL 240
            .|:|:.:|:||.|:|:.:|.|.|..|||..||.||||.:|.|.....:...|      ..|||.:
  Rat   209 GGNPKSVTLFGESAGAASVSLHLLCPQSYPLFTRAILESGSSNAPWAVKHPEEARNRTLTLAKFI 273

  Fly   241 GYEGDNVDSQVLEFLLKADP-ALIVSADFFTPLEKRQGHNMPFKPSIES---YSTPNAVLLAEPI 301
            |...:| :.:::..|...|| .::::.....|.:..:..|  |.|:::.   ...|:.:|....:
  Rat   274 GCSKEN-EKEIITCLRSKDPQEILLNEKLVLPSDSIRSIN--FGPTVDGDFLTDMPHTLLQLGKV 335

  Fly   302 DLQRTTWSNRIPIILGANSGEGMSIF-----SFVKMNPSWL--KEFQCNPERVLPWTLRNRCDPG 359
            ...:        |::|.|..||.:..     .|.|.|.|.:  :|||   |.:      |...||
  Rat   336 KTAQ--------ILVGVNKDEGTAFLVYGAPGFSKDNDSLITRREFQ---EGL------NMYFPG 383

  Fly   360 QRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGFVHAMDRLIQSRLTYGQAPTYLYRF-DFD 423
            ......:|::.::.:..|     |.|   .|::...|    |.:|........|..:..:| :.:
  Rat   384 VSSLGKEAILFYYVDWLG-----DQT---PEVYREAF----DDIIGDYNIICPALEFTKKFAELE 436

  Fly   424 SPDFNFYRIRFMGK----EQRGVGHVDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQFAATS 484
            ...|.:|......|    |..||.|..|:.::|.||...:::.:|.|....|.::..:..||...
  Rat   437 INAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTRAEEIFSRSIMKTWANFAKYG 501

  Fly   485 DPNAPLTKSLVDWKPVTRFGKRMVLNISEELKFI------PQPEMPKLKFFDRLYEMAG 537
            .||.....|.| | ||....::..|.::.|...|      ||.:..:| ||.::.|:.|
  Rat   502 HPNGTQGNSTV-W-PVFTSTEQKYLTLNTEKSKINSKLRAPQCQFWRL-FFPKVLEITG 557

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-Est4NP_524266.1 alpha/beta hydrolases 8..529 CDD:473884 162/566 (29%)
BcheNP_075231.1 COesterase 25..545 CDD:395084 161/561 (29%)
AChE_tetra 560..594 CDD:430146
Blue background indicates that the domain is not in the aligned region.

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