DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Est4 and BCHE

DIOPT Version :9

Sequence 1:NP_524266.1 Gene:alpha-Est4 / 40906 FlyBaseID:FBgn0015572 Length:541 Species:Drosophila melanogaster
Sequence 2:NP_000046.1 Gene:BCHE / 590 HGNCID:983 Length:602 Species:Homo sapiens


Alignment Length:578 Identity:166/578 - (28%)
Similarity:269/578 - (46%) Gaps:87/578 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 YNEDAPVVQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPL 69
            :.||..::.|.:|||||:.| :::.....||.|||||.||||.||||:|..|..|..|.:.:|..
Human    27 HTEDDIIIATKNGKVRGMNL-TVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYA 90

  Fly    70 SKCLQVSTLTKEVEG-------------SEDCLYLNISVKTLNGDPMPVMVYIHGGAFKGGDSSR 121
            :.|.|  .:.:...|             ||||||||:.:.........|:::|:||.|:.|.||.
Human    91 NSCCQ--NIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSL 153

  Fly   122 RAWGPDYFMK-ENVVYISIGHRLGPLGFLSL-NDPDLEVPGNAGLKDVILALRWIRANAANFNGD 184
            ..:...:..: |.|:.:|:.:|:|.||||:| .:|  |.|||.||.|..|||:|::.|.|.|.|:
Human   154 HVYDGKFLARVERVIVVSMNYRVGALGFLALPGNP--EAPGNMGLFDQQLALQWVQKNIAAFGGN 216

  Fly   185 PERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAG-FS-----MELNRLPQMEYRLAKHLGYE 243
            |:.:|:||.|:|:.:|.|.|.||.|..||.||||.:| |:     ..|.........|||..|..
Human   217 PKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCS 281

  Fly   244 GDNVDSQVLEFLLKADPALIVSADFF-----TPLEKRQGHNMPFKPSIE-SYSTPNAVLLAEPID 302
            .:| ::::::.|...||..|:..:.|     |||      ::.|.|::: .:.|....:|.|...
Human   282 REN-ETEIIKCLRNKDPQEILLNEAFVVPYGTPL------SVNFGPTVDGDFLTDMPDILLELGQ 339

  Fly   303 LQRTTWSNRIPIILGANSGEGMSIF-----SFVKMNPSWL--KEFQCNPERVLPWTLRNRCDPGQ 360
            .::|      .|::|.|..||.:..     .|.|.|.|.:  ||||...:...|..         
Human   340 FKKT------QILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGV--------- 389

  Fly   361 RRQLG-QALIHHFCEAHGHELTVDHTNGLVELF-THGFVHAMDRLIQSRLTYGQAPTYLYRFDFD 423
             .:.| ::::.|:.:....:...::...|.::. .:.|:.......:....:|. ..:.|.|:..
Human   390 -SEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGN-NAFFYYFEHR 452

  Fly   424 SPDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQFAATSDPNA 488
            |.       :....|..||.|..|:.::|.||...:.:.::.|....|.:|..:..||...:||.
Human   453 SS-------KLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNPNE 510

  Fly   489 PLTKSLVDWKPVTRFGKRMVLNISEELKFIPQPEMPKLK---------FFDRLYEMAG 537
            ....| ..| ||.:..::..|.::.|...|    |.||:         ||.::.||.|
Human   511 TQNNS-TSW-PVFKSTEQKYLTLNTESTRI----MTKLRAQQCRFWTSFFPKVLEMTG 562

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
alpha-Est4NP_524266.1 Abhydrolase 7..529 CDD:304388 161/566 (28%)
Aes <104..>219 CDD:223730 51/116 (44%)
BCHENP_000046.1 COesterase 30..550 CDD:395084 160/561 (29%)