Protein Alignment alpha-Est4 and NLGN2

DIOPT Version :9

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_065846.1
• Gene: NLGN2 / 57555
• HGNCID: 14290
• Length: 835
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 174/585 - (29%)
• Similarity: 257/585 - (43%)
• Gaps: 146/585 - (24%)

  Fly     7 EDAPVVQTTHGKVRGILLKSLYDE---QFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRD---- 64
            |..|||.|.:|:|||: .:.|.:|   ....|.|:|||.||||..||:.|.....|.|:|:
Human    39 ERFPVVNTAYGRVRGV-RRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTL 102

  Fly    65 ---CSKPLSKCLQVSTL----TKEVEG--------SEDCLYLNISVKTLNG-------------- 100
               |.:.|...|....|    |..:|.        ||||||||:.|.|.:|
Human   103 PPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPP 167

  Fly   101 -----DP--MPVMVYIHGGAFKGG------DSSRRAWGPDYFMKENVVYISIGHRLGPLGFLSLN 152
                 ||  .|||:::|||::..|      .|...|:|       ||:..::.:|||.|||||..
Human   168 DTDIRDPGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYG-------NVIVATLNYRLGVLGFLSTG 225

  Fly   153 DPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAI 217
            |.  ...||.||.|.|.||||:..|.|:|.||||||||||..:|:..|.||:.|..|||||.:||
Human   226 DQ--AAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAI 288

  Fly   218 LLAG---FSMELNRLPQMEYR--LAKHLGYEGDNVDSQVLEFLLKADPALIVSADFFTPLEKRQG 277
            ..:|   .|..:|..| ::|.  ||..:|.:.:: .::.:|.|.:.....:|..|.     :...
Human   289 AQSGTAISSWSVNYQP-LKYTRLLAAKVGCDRED-SAEAVECLRRKPSRELVDQDV-----QPAR 346

  Fly   278 HNMPFKPSIESYSTPNAVLLAEP-IDLQRTTWSNRIPIILGANSGEGM---------------SI 326
            :::.|.|.::....|:     :| |.:|:..:.| ..:::|.|.|||:               |.
Human   347 YHIAFGPVVDGDVVPD-----DPEILMQQGEFLN-YDMLIGVNQGEGLKFVEDSAESEDGVSASA 405

  Fly   327 FSFVKMNPSWLKEFQCNPE--RVLPWTLR-------NRCDPGQRRQLGQALIHHFCEAHGHELTV 382
            |.|...|  ::......||  .||..|::       :| |.|:.|:
Human   406 FDFTVSN--FVDNLYGYPEGKDVLRETIKFMYTDWADR-DNGEMRR------------------- 448

  Fly   383 DHTNGLVELFT-HGFVHAMDRLIQSRLTYGQAPTYLYRFDFDSPDFNFYRIRFMGK-EQRGVGHV 445
               ..|:.||| |.:|.......:....| |:|.|.|.|        ::..:..|: |.....|.
Human   449 ---KTLLALFTDHQWVAPAVATAKLHADY-QSPVYFYTF--------YHHCQAEGRPEWADAAHG 501

  Fly   446 DELGYIFKLP---AT--FKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTK--SLVDWKPVTRF 503
            |||.|:|.:|   ||  |..:.|:.:......::..:..||.|.|||.|:.:  ..:..|| .||
Human   502 DELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKP-NRF 565

  Fly   504  503
            Human   566  565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	174/585 (30%)
		Aes	<104..>219	CDD:223730	56/120 (47%)
NLGN2	NP_065846.1	COesterase	41..601	CDD:278561	173/583 (30%)
		Aes	<170..>268	CDD:223730	46/106 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..668
		Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9	678..698
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	790..835

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142790
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740