Protein Alignment alpha-Est4 and NCEH1

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_001139748.2
• Gene: NCEH1 / 57552
• HGNCID: 29260
• Length: 416
• Species: Homo sapiens
• Alignment Length: 375
• Identity: 85/375 - (22%)
• Similarity: 136/375 - (36%)
• Gaps: 120/375 - (32%)

  Fly    74 QVSTLTKEVEGSEDCLYLNISVKTLNGDPMP------VMVYIHGGAFKGGDSSRRAWGPD----Y 128
            ||.....:.:|        :.|:...|.|.|      .:||||||.:....:| .:|.|.    |
Human    79 QVKVTDTDFDG--------VEVRVFEGPPKPEEPLKRSVVYIHGGGWALASAS-ASWSPSDEIRY 134

  Fly   129 F------MKE--NVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAA--NFNG 183
            :      |.|  |.|.:||.:||.|..:.    |:       .:.||:.|.::......  .:..
Human   135 YDELCTAMAEELNAVIVSIEYRLVPKVYF----PE-------QIHDVVRATKYFLKPEVLQKYMV 188

  Fly   184 DPERITIFGHSS-GSMTVQLLLASPQSEGLFHRAILLA--------------GFSMELNR--LPQ 231
            ||.||.|.|.|: |::...|.....|...|.::..|.|              .:...:|.  ||:
Human   189 DPGRICISGDSAGGNLAAALGQQFTQDASLKNKLKLQALIYPVLQALDFNTPSYQQNVNTPILPR 253

  Fly   232 MEYRLAKH-LGYEGDNVDSQVLEFLLKADPALIV----SADFFTPLEKRQGHN----MP------ 281
              |.:.|: :.|...|.|     |:    .|:||    |.|.......|...|    :|
Human   254 --YVMVKYWVDYFKGNYD-----FV----QAMIVNNHTSLDVEEAAAVRARLNWTSLLPASFTKN 307

  Fly   282 FKPSIESYSTPNAVLLAEPIDLQRTTWSNRIPIILGANSGEGMSIFSFVKMNPSWLKEFQCNPER 346
            :||.::  :|.||.::.|            :|.:|.|.|...::..:.:::
Human   308 YKPVVQ--TTGNARIVQE------------LPQLLDARSAPLIADQAVLQL-------------- 344

  Fly   347 VLPWTLRNRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGF 396
             ||.|....|:....|..| .:.....|:.|.|:|:||       |..||
Human   345 -LPKTYILTCEHDVLRDDG-IMYAKRLESAGVEVTLDH-------FEDGF 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	85/375 (23%)
NCEH1	NP_001139748.2	Abhydrolase_3	109..389	CDD:400284	78/337 (23%)