Protein Alignment alpha-Est4 and NLGN4X

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: XP_005274621.1
• Gene: NLGN4X / 57502
• HGNCID: 14287
• Length: 836
• Species: Homo sapiens
• Alignment Length: 629
• Identity: 177/629 - (28%)
• Similarity: 253/629 - (40%)
• Gaps: 168/629 - (26%)

  Fly     4 DYNEDAPVVQTTHGKVRGI-------LLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHG 61
            |.....|||.|.:||:||:       :|..:  ||:.   |:|||.||.|..||:.|.....|.|
Human    40 DSQAQYPVVNTNYGKIRGLRTPLPNEILGPV--EQYL---GVPYASPPTGERRFQPPEPPSSWTG 99

  Fly    62 IRDCSKPLSKCLQ-------------------VSTLTKEVEG-SEDCLYLNISVKTLNG------ 100
            ||:.::..:.|.|                   :.||...|:. :||||||||.|.|.:|
Human   100 IRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDGANTKKN 164

  Fly   101 -------------------DPMPVMVYIHGGAFKGG-----DSSRRA-WGPDYFMKENVVYISIG 140
                               ...|||||||||::..|     |.|..| :|       ||:.|:|.
Human   165 ADDITSNDRGEDEDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYG-------NVIVITIN 222

  Fly   141 HRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQLLLA 205
            :|||.|||||..|.  ...||.||.|.|.|||||..|...|.|||:|:||||..:|:..|.||..
Human   223 YRLGILGFLSTGDQ--AAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTL 285

  Fly   206 SPQSEGLFHRAILLAGFSME---LNRLPQMEYRLAKHLGYEGDNVDSQVLEFLLKADPALIVSAD 267
            |..|||||.:||:.:|.::.   :|      |:.||:.....|.|...:|:           :.|
Human   286 SHYSEGLFQKAIIQSGTALSSWAVN------YQPAKYTRILADKVGCNMLD-----------TTD 333

  Fly   268 FFTPLEKRQGHNMPFKPSIESYSTPNAVLLA------------EPIDLQRTTWSNRIPIILGANS 320
            ....|     .|..:|..|:...||....:|            :|..|..........|:||.|.
Human   334 MVECL-----RNKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQ 393

  Fly   321 GEGMSIFSFVKMNPSWLKEFQCNPERVLP----WTLRNRCD-----PGQRRQLGQALIHHFCEAH 376
            |||:          .::.....|.:.|.|    :::.|..|     |..:..|.:.:...:.:..
Human   394 GEGL----------KFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWA 448

  Fly   377 GHELTVDHTNGLVELFT-HGFVHAMDRLIQSRLTYGQAPTYLYRFDFDSPDFNFYRIRF-MGKEQ 439
            ..|........||.||| |.:|............|| :|||.|.|        ::..:. |....
Human   449 DKENPETRRKTLVALFTDHQWVAPAVATADLHAQYG-SPTYFYAF--------YHHCQSEMKPSW 504

  Fly   440 RGVGHVDELGYIFKLP-----ATFKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTK--SLVDW 497
            ....|.||:.|:|.:|     ..|..:.|:.:......::..:..||.|.|||.|:.:  ..:..
Human   505 ADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHT 569

  Fly   498 KPVTRFGKRMVLNISEEL---KFIPQPEMPKLKFFDRLYEMAGV 538
            || .||         ||:   |:.|:         |:||...|:
Human   570 KP-NRF---------EEVAWSKYNPK---------DQLYLHIGL 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	172/614 (28%)
NLGN4X	XP_005274621.1	COesterase	44..610	CDD:395084	176/625 (28%)