Protein Alignment alpha-Est4 and Aadac

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_065413.1
• Gene: Aadac / 57300
• RGDID: 631440
• Length: 398
• Species: Rattus norvegicus
• Alignment Length: 271
• Identity: 55/271 - (20%)
• Similarity: 95/271 - (35%)
• Gaps: 109/271 - (40%)

  Fly    92 NISVKTLNGDPMPVMVY---------------IHGGAFKGGDSSRRAWGPDYFMKE--------- 132
            |::|...:.:.:||.:|               ||||.:..|.::       |||.:
  Rat    77 NVTVMETDFNSVPVRIYIPKRKSTTLRRGLFFIHGGGWCLGSAA-------YFMYDTLSRRTAHR 134

  Fly   133 -NVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRAN--AANFNGDPERITIFGHS 194
             :.|.:|..:.|.         |....|..  .:||..:|||....  ...:..||.|:.:.|.|
  Rat   135 LDAVVVSTDYGLA---------PKYHFPKQ--FEDVYHSLRWFLQEDILEKYGVDPRRVGVSGDS 188

  Fly   195 SG----SMTVQLLLASP------QSEGLFHRAILLAGFSMELNRLPQME---YRLAKHLGYEGDN 246
            :|    :...|.:|..|      :.:.|.:.|:.    ::::|...|.|   |.|...
  Rat   189 AGGNLTAAVTQQILQDPDVKIKLKVQALIYPALQ----ALDMNVPSQQENSQYPLLTR------- 242

  Fly   247 VDSQVLEFLLKADPALIVSADFFT---PLEKRQGHNMPFKPSIESYSTPNAVLLAE--PID---- 302
              |.::.|.          :::||   .|||                   |:||.:  |::
  Rat   243 --SLLIRFW----------SEYFTTDRDLEK-------------------AMLLNQHVPVEFSHL 276

  Fly   303 LQRTTWSNRIP 313
            ||...||:.:|
  Rat   277 LQFVNWSSLLP 287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	55/271 (20%)
Aadac	NP_065413.1	Abhydrolase_3	106..373	CDD:400284	50/242 (21%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	110..112		1/1 (100%)