DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est4 and cel.2

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001020344.2	Gene:	cel.2 / 565117	ZFINID:	ZDB-GENE-061110-10	Length:	551	Species:	Danio rerio

Alignment Length:	535	Identity:	159/535 - (29%)
Similarity:	236/535 - (44%)	Gaps:	83/535 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCLQVSTLTKE 81
            ||...:.|....|    .|.|||:|.|| |.|:...||  ..|.|:...::...:|:|::.|..:
Zfish    35 GKSHSVGLLRYMD----VFKGIPFAAPP-GRLQKPVPH--PGWEGVLKATEYSKRCIQLNLLQTD 92

  Fly    82 VEGSEDCLYLNISV---KTLNGDPMPVMVYIHGGAFKGGDSSRRAWGPDYFM-------KENVVY 136
            ..||||||||||.|   ||::.: :||||:|:||.|..|......:..:|..       :.||:.
Zfish    93 TMGSEDCLYLNIWVPQGKTVSYN-LPVMVFIYGGGFLLGGGQGANFLDNYLYDGEEIADRGNVIV 156

  Fly   137 ISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQ 201
            ::..:|:|.:||||..|.|  .|||.||.|...|:.|:..|...|.|:|:.|||||.|:||.:|.
Zfish   157 VTFNYRVGSMGFLSTGDAD--APGNYGLWDQHAAISWVHRNIKAFGGNPDNITIFGESAGSTSVN 219

  Fly   202 LLLASPQSEGLFHRAILLAGFSM---ELNRLP-QMEYRLAKHLGYEGDNVDSQVLEFLLKADPAL 262
            ..:.||:::||..|||..:|.::   .:||.| :....:||.:|..   .||.::..|.:.||..
Zfish   220 FQIISPKNKGLIRRAISQSGVALCPWAINRNPRKFAEEIAKKVGCP---TDSGMVACLRRTDPKA 281

  Fly   263 IVSAD---FFTPLEKRQGHNMPFKPSIESYSTPNAVLLAEPIDLQRTTWSNR--IPIILGANSGE 322
            :..|.   ..|...:...||:...|.|:....|:     ||    .|.:.|.  |..|.|.|..:
Zfish   282 VTLAGKVRLATSATEPIVHNLYLSPVIDGDFIPD-----EP----DTLFGNAADIDYIAGVNDMD 337

  Fly   323 GMSIFSFVKMNPSWLKEFQCNPE---RVLPWTLRNRCDPGQRRQLGQALIHHFCEAHGH------ 378
            | .||:.:.: ||.........|   :.|...|..  |.||  ..|.|....:....|.
Zfish   338 G-HIFATLDI-PSINNALATTTEEEVQALATALSK--DRGQ--DAGIATFQEYTVNWGSKPNKED 396

  Fly   379 ------ELTVDHTNGLVELFTHGFVHAMDRLIQSRLTYGQAPTYLYRFDFDS--PDFNFYRIRFM 435
                  |:..|:. .||...|..::|: |....:|       ||.|.|...|  |.|..:
Zfish   397 IKKTVVEMETDYI-FLVPTQTALYLHS-DNAKSAR-------TYSYLFSESSRIPIFPLW----- 447

  Fly   436 GKEQRGVGHVDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTKSLVDWKPV 500
                .|..|.|||.|:|..|.|..|..........:.::|.:..||.|.:||...:|..|.|...
Zfish   448 ----MGADHADELQYVFGKPFTTPLGYFPRHRDVSKYMIAYWTNFAQTGNPNTGESKVPVTWPEF 508

  Fly   501 TRFGKRMVLNISEEL 515
            :..| ...|:|:.::
Zfish   509 SNPG-HQYLDINNKI 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	159/535 (30%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	48/121 (40%)
cel.2	NP_001020344.2	COesterase	26..539	CDD:306613	159/535 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575582
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.740