DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and si:dkey-30c15.17

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_003200472.2	Gene:	si:dkey-30c15.17 / 561375	ZFINID:	ZDB-GENE-060503-450	Length:	657	Species:	Danio rerio

Alignment Length:	575	Identity:	168/575 - (29%)
Similarity:	257/575 - (44%)	Gaps:	88/575 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SDDYNEDA----PVVQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGI 62
            |.|..||.    |||.|..|:|||:.|     |:.:.|.|||||.||:|..|:..|..:.||...
Zfish   124 SSDGLEDGSGADPVVVTLLGRVRGLTL-----EKAHVFYGIPYADPPVGDKRWAPPSPVSPWLYT 183

  Fly    63 RDCSKPLSKCLQV-----STLTKEVEGSEDCLYLNISVK-TLN-----GDPMPVMVYIHGGAFKG 116
            .:.:.|...|:|:     |.|... |.||||||||:.|. ::|     ...:||||:||||.|..
Zfish   184 YNATFPRPACMQMCAGEFSRLCPP-EVSEDCLYLNVFVPVSVNLSLPKVTALPVMVWIHGGDFIA 247

  Fly   117 GDSSRRAWGPDYFMK-ENVVYISIGHRLGPLGFL-SLNDPDLEVPGNAGLKDVILALRWIRANAA 179
            |.:|:..:...|... .|.|.:::.:|||..||| :..||:....||.|:.|...||.|::.|.|
Zfish   248 GSASKPLYDGRYISNYSNTVVVNMEYRLGAFGFLVTGKDPESSAVGNYGILDQQAALHWVQENIA 312

  Fly   180 NFNGDPERITIFGHSSGSMTVQLLLASPQSEGLF-HRAILLAGFSMEL-NRLPQMEYRLAKHLGY 242
            .|.|||.::|:||.|:|:.:|.|.|....||.|| |.||....||:.| .|...|:      ||:
Zfish   313 AFGGDPNKVTLFGESAGAQSVSLHLMMQSSETLFRHAAIQSLPFSLPLKTRWDAMK------LGW 371

  Fly   243 EGDNV------DSQVLEFLLKADPALIVSADFFTPLEKRQGHNM--PFKPSIESYST-----PNA 294
            :...:      |...:..|...|   :::|..      :.|..:  ||: .:|.:.|     ...
Zfish   372 DFAKLTNCSVFDLPCMRSLSSED---VLNAQI------KSGSKIINPFR-FLEVFETWGPFIDGQ 426

  Fly   295 VLLAEPID-LQRTTWSNRIPIILGANSGEGMSIFSFVKMNPSWLKEFQCNPERVLPWTLRNRCDP 358
            :|..:||. .|:..|.:..|:|||..|.||: :|.:...|.| :...:|    || :|      .
Zfish   427 LLKEQPITAFQKGHWQSYKPVILGTTSEEGV-MFVYRNFNKS-VSMLEC----VL-YT------A 478

  Fly   359 GQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFT-HGFVHAMDRLIQSRLTYGQAPTYLYRFDF 422
            ...:|....::|.:...:.::   |....|.::.| :.|.....:..:|.:..|.| .::|.||.
Zfish   479 AIFKQHALKILHKYIPFYRNQ---DRRVMLSQMVTDYVFSCPARQSARSGVKVGGA-VWMYVFDH 539

  Fly   423 DSPDFNFY-RIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQFAATSDP 486
            ...|.|.: .:.|.....   .|..||.::|....:.....:..|.....|:...:..||.|.||
Zfish   540 APSDPNIWAELTFCYNHS---CHGAELPFLFDSAPSTNFTFTPQERLLANRMACYWGMFAHTGDP 601

  Fly   487 NAP-------LTKSLVDWKPVTRFGKRMVLNISEELKFIPQPEMPK--LKFFDRL 532
            |:.       ..:.|..|...|..|...:||::  |:..||.....  ..|:|||
Zfish   602 NSRDEQTHFCREQRLPVWPRYTDIGGWTILNLT--LQSHPQHGSRDHFCDFWDRL 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	162/565 (29%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	50/117 (43%)
si:dkey-30c15.17	XP_003200472.2	COesterase	134..651	CDD:306613	160/560 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575424
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840