Protein Alignment alpha-Est4 and nlgn2a

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: XP_009301340.1
• Gene: nlgn2a / 556158
• ZFINID: ZDB-GENE-090918-2
• Length: 828
• Species: Danio rerio
• Alignment Length: 575
• Identity: 163/575 - (28%)
• Similarity: 256/575 - (44%)
• Gaps: 130/575 - (22%)

  Fly    10 PVVQTTHGKVRGILLKSLYD------EQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKP 68
            |.|.|.:||:||| .|.|.:      ||:.   |:|||..|:|..||:.|.....|..:|:.::.
Zfish    47 PTVTTNYGKLRGI-KKELNNEILGPVEQYL---GVPYATAPIGDRRFQPPEAPGSWQEVRNATQF 107

  Fly    69 LSKCLQ-VSTLTKEV------------------EGSEDCLYLNISVKTLNGDPM----------- 103
            ...|.| |..:..|:                  ..||||||||:.|.|.:| |:
Zfish   108 APVCPQNVHGVLPEIMLPVWFTDSLDVAATYIQNQSEDCLYLNVYVPTEDG-PLTKKHDESTLNR 171

  Fly   104 ------------PVMVYIHGGAFKGG-----DSS-RRAWGPDYFMKENVVYISIGHRLGPLGFLS 150
                        |||::||||::..|     |:| ..|:|       ||:.:::.:|||.|||||
Zfish   172 PRDEDIRDRRKKPVMLFIHGGSYMEGTGNMFDASVLAAYG-------NVIVVTMNYRLGVLGFLS 229

  Fly   151 LNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHR 215
            ..|...:  ||.||.|.|.||||:..|..:|.||||||||||..:|:..|.||:.|..|||||.|
Zfish   230 TGDQSAK--GNYGLLDQIQALRWLNENIGHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQR 292

  Fly   216 AILLAG---FSMELNRLPQMEYR--LAKHLGYE-GDNVDSQVLEFLLKADPALIVSADFFTPLEK 274
            ||..:|   .|..::..| ::|.  ||:.:|.. |:..|  :::.|.:.:...:|..|.     :
Zfish   293 AIAQSGSAISSWSISYQP-LKYTKILARKVGCTYGETAD--LVDCLRRKNFRELVDQDI-----Q 349

  Fly   275 RQGHNMPFKPSIESYSTPNAVLLAEP-IDLQRTTWSNRIPIILGANSGEGMSIFSFVKMNPSWLK 338
            ...:::.|.|.::....|:     :| |.:|:..:.| ..:::|.|.|||:..     ::....:
Zfish   350 PARYHIAFGPVMDGDVVPD-----DPEILMQQGEFLN-YDLLIGVNQGEGLKF-----VDDGGTE 403

  Fly   339 EFQCNPERVLPWTLRNRCD-----PGQRRQLGQALIHHFCEAHGHELTVDHTNG------LVELF 392
            ..:........:|:.|..|     |..:..|.:.:...:.:      ..|..||      |:.||
Zfish   404 SEEGISAAAFDYTISNFVDNLYGYPKGKDILRETIKFMYTD------WADRDNGEMRRKTLLALF 462

  Fly   393 T-HGFVHAMDRLIQSRLTYGQAPTYLYRFDFDSPDFNFYRIRFMGK-EQRGVGHVDELGYIFKLP 455
            | |.:|.......:....| |:|.|.|.|        ::..:...: |.....|.||:.|:|.:|
Zfish   463 TDHQWVAPAIATAKLHADY-QSPVYFYTF--------YHHCQTETRPEWADAAHGDEIPYVFGVP 518

  Fly   456 ---AT--FKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTK--SLVDWKPVTRF 503
               ||  |..:.|:.:......::..:..||.|.|||.|:.:  ..:..|| .||
Zfish   519 MIGATDLFPCNFSKNDIMLSAVVMTYWTNFAKTGDPNLPVPQDTKFIHTKP-NRF 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	163/575 (28%)
nlgn2a	XP_009301340.1	COesterase	47..608	CDD:395084	163/575 (28%)