Protein Alignment alpha-Est4 and NLGN3

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Alignment Length: 626
• Identity: 175/626 - (27%)
• Similarity: 248/626 - (39%)
• Gaps: 154/626 - (24%)

  Fly     9 APVVQTTHGKVRGILLKSLYDEQFYAFD---GIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLS 70
            ||.|.|..||:||..: .|..|.....|   |:|||.||:|..||..|.....|.|||:.:....
Human    41 APTVNTHFGKLRGARV-PLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPP 104

  Fly    71 KCLQ-VSTLTKEV------------------EGSEDCLYLNISVKT------------------- 97
            .|.| :.|...||                  |.:|||||||:.|.|
Human   105 VCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKIC 169

  Fly    98 ----------------LNGD---------PMPVMVYIHGGAFKGG-----DSSRRA-WGPDYFMK 131
                            .:||         ..|||||||||::..|     |.|..| :|
Human   170 RKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSILASYG------ 228

  Fly   132 ENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSG 196
             ||:.|::.:|:|.|||||..|.  ...||.||.|.|.||||:..|.|.|.|||.|||:||...|
Human   229 -NVIVITLNYRVGVLGFLSTGDQ--AAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIG 290

  Fly   197 SMTVQLLLASPQSEGLFHRAILLAGFSME---LNRLPQMEYRLAKHLGYEGDNVDSQVLEFLLKA 258
            :..|.||..|..|||||.|||:.:|.::.   :|      |:..|:.....|.|...||:.:...
Human   291 ASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVN------YQPVKYTSLLADKVGCNVLDTVDMV 349

  Fly   259 DPALIVSADFFTPLEKRQG-HNMPFKPSIESYSTPNAVLLAEPIDLQRTTWSNRIPIILGANSGE 322
            |.....||......:.:.. :::.|.|.|:....|:     :|..|..........|:||.|.||
Human   350 DCLRQKSAKELVEQDIQPARYHVAFGPVIDGDVIPD-----DPEILMEQGEFLNYDIMLGVNQGE 409

  Fly   323 GMSIFSFVKMNPSWLKEFQCNPE-----RVLPWTLRNRCD-----PGQRRQLGQALIHHFCEAHG 377
            |:   .||        |...:||     ....:::.|..|     |..:..|.:.:...:.:...
Human   410 GL---KFV--------EGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWAD 463

  Fly   378 HELTVDHTNGLVELFT-HGFVHAMDRLIQSRLTYGQAPTYLYRFDFDSPDFNFYRIRFMGKEQ-R 440
            .:........||.||| |.:|............|| :|||.|.|        ::..:.:.|.. .
Human   464 RDNPETRRKTLVALFTDHQWVEPSVVTADLHARYG-SPTYFYAF--------YHHCQSLMKPAWS 519

  Fly   441 GVGHVDELGYIFKLPAT-----FKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTKSLVDWKPV 500
            ...|.||:.|:|.:|..     |..:.|:.:......::..:..||.|.|||.|:.:.
Human   520 DAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQD------- 577

  Fly   501 TRFGKRMVLNISEEL---KFIPQPEMPKLKFFDRLYEMAGV 538
            |:| .....|..||:   |:.|:         |:||...|:
Human   578 TKF-IHTKANRFEEVAWSKYNPR---------DQLYLHIGL 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	171/615 (28%)
NLGN3	NP_851820.1	COesterase	40..624	CDD:395084	175/626 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		2/24 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694