DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est4 and ACHE

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001354847.1	Gene:	ACHE / 43	HGNCID:	108	Length:	681	Species:	Homo sapiens

Alignment Length:	550	Identity:	167/550 - (30%)
Similarity:	244/550 - (44%)	Gaps:	90/550 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EDAPVVQTTH-GKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLS 70
            |||.::.|.. |::|||.||: ......||.|||:|.||:|..||..|...:||.|:.|.:...|
Human   102 EDAELLVTVRGGRLRGIRLKT-PGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQS 165

  Fly    71 KCLQ-VSTLTKEVEG----------SEDCLYLNI-SVKTLNGDPMPVMVYIHGGAFKGGDSSRRA 123
            .|.| |.||....||          ||||||||: :.......|.||:|:|:||.|..|.||...
Human   166 VCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDV 230

  Fly   124 WGPDYFMK-ENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPER 187
            :...:.:: |..|.:|:.:|:|..|||:| ....|.|||.||.|..|||:|::.|.|.|.|||..
Human   231 YDGRFLVQAERTVLVSMNYRVGAFGFLAL-PGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTS 294

  Fly   188 ITIFGHSSGSMTVQLLLASPQSEGLFHRAIL----------LAGFSMELNRLPQMEYRLAKHLGY 242
            :|:||.|:|:.:|.:.|.||.|.||||||:|          ..|......|..|:.:.:....|.
Human   295 VTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGG 359

  Fly   243 EGDNVDSQVLEFLLKADPALIVSADFFTPLEKRQGHNMPFKPSIES---YSTPNAVLLAEPIDLQ 304
            .|.| |::::. .|:..||.::....:..|.:.......|.|.::.   ..||.|::.|...
Human   360 TGGN-DTELVA-CLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDF--- 419

  Fly   305 RTTWSNRIPIILGANSGEGMSIF------SFVKMNPSWLK--EFQCNPERVLPWTLRNRCDPGQR 361
                 :.:.:::|....|| |.|      .|.|.|.|.:.  ||.......:|          |.
Human   420 -----HGLQVLVGVVKDEG-SYFLVYGAPGFSKDNESLISRAEFLAGVRVGVP----------QV 468

  Fly   362 RQL-GQALIHHFCE-------AHGHELTVDHTNGLVELFTHGFVHAMDRLIQSRLTYGQAPTYLY 418
            ..| .:|::.|:.:       |...|...|...      .|..|..:.:| ..||....|..|.|
Human   469 SDLAAEAVVLHYTDWLHPEDPARLREALSDVVG------DHNVVCPVAQL-AGRLAAQGARVYAY 526

  Fly   419 RFDFDSPDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSRPEFTA-----IRRLVAMFV 478
            .|:..:...::       ....||.|..|:.:||.:|    ||.|| .:||     .:||:..:.
Human   527 VFEHRASTLSW-------PLWMGVPHGYEIEFIFGIP----LDPSR-NYTAEEKIFAQRLMRYWA 579

  Fly   479 QFAATSDPNAPLTKSLVDWKPVTRFGKRMV 508
            .||.|.|||.|.......|.|.|...::.|
Human   580 NFARTGDPNEPRDPKAPQWPPYTAGAQQYV 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	166/549 (30%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	53/125 (42%)
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	164/547 (30%)
ACHE	NP_001354847.1	AChE_tetra	645..678	CDD:400834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142773
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840