DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and CG10175

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	191/563 - (33%)
Similarity:	283/563 - (50%)	Gaps:	56/563 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VVQTTHGKVRGILLKSLYDEQ--FYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCL 73
            |..|:.|||||...|....|:  :|:|.|:.|..||.|..||:.....|||.||||.|:....|.
  Fly   155 VATTSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSCP 219

  Fly    74 QVSTLTKEVEGSEDCLYLNISVKTLNGD-------PMPVMVYIHGGAFKGGDSSRRAWGPDYFMK 131
            ..:.:....:|.||||::|:....:..|       .:||||::|||.|..|..:...:||||.:.
  Fly   220 HKNMILDTFKGDEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGGFSFGSGNSFLYGPDYLVA 284

  Fly   132 ENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSG 196
            |::|.:::.:||||||||:.. ||  .|||.||||.:|||:|:|.|.|.|.|||.::||||.|:|
  Fly   285 EDIVLVTLNYRLGPLGFLTAG-PD--APGNQGLKDQVLALKWVRDNIAAFGGDPNQVTIFGESAG 346

  Fly   197 SMTVQLLLASPQSEGLFHRAILLAG-----FSMELNRLPQMEYRLAKHLGYEGDNVDSQVLEFLL 256
            :.:|||||.|.|::|||||||..:|     :||..:. .|...|||.:|||.|.|....:|:||.
  Fly   347 ASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASS-SQRAARLAANLGYVGANKTEDILDFLR 410

  Fly   257 KADPALIVSA--DFFTPLEKRQGHNMPFKPSIESYSTPNA---------VLLAEPIDLQRT-TWS 309
            :.....:|.|  ...|..::|....:||.|.:|.|...::         .|...|.|:..: .::
  Fly   411 RVPAMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQFYEEPFLTQHPSDMYHSQNFN 475

  Fly   310 NRIPIILGANSGEGMSIFSFVKMNPSWLKEFQCNPERVLPWTLRNRCDPGQR--RQLGQALIHHF 372
            :.:..:.|.|:.|.|.....::.||..|...:.:..|::|..| |..:...|  |:     |..|
  Fly   476 SDVAYMTGYNTHEAMLFIRRLRKNPQLLSIIENDFGRLVPQDL-NVTESHDRVTRE-----IRSF 534

  Fly   373 CEAHGHELTVDHTNGLVELFTH-GFVHAMDRLIQSRLTYGQAPTYLYRFDFDSPDFNFYRIRFMG 436
            .....| :.::..:.::.|.|. .|:..:.|..::...:|.||.|:|||.||. ....|: |.:|
  Fly   535 YLGSKH-VGIESVDEMIALLTDLMFLQGIRRTARNHAKFGNAPVYMYRFSFDG-SLGLYK-RMLG 596

  Fly   437 KEQRGVGHVDELGYIFKLP-ATFKLDKSRPEFTAIRRLVAMFVQFA----ATSDPNAPL--TKSL 494
            ..:.||.|.|||||:||.. ....||....|.....|:|.|:..||    .|.|...|:  ||
  Fly   597 IPRPGVCHGDELGYLFKFGFFNLSLDPKSMEVQVKNRMVRMWTNFAKYGSPTPDSEDPMLTTK-- 659

  Fly   495 VDWKPVTRFGKRMVLN---ISEELKFIPQPEMPKLKFFDRLYE 534
              |.|:........||   ||..|.....||..:.:|:|.:|:
  Fly   660 --WAPIDPTNVMNSLNYMDISANLAMKTNPEPERQRFWDEMYQ 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	188/556 (34%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	63/114 (55%)
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	187/554 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	7	6.860