DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and Ace

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	567	Identity:	148/567 - (26%)
Similarity:	234/567 - (41%)	Gaps:	135/567 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DAPVVQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKC 72
            |..||||:.|.|||..: ::...:.:.:.|||||.||:..|||::|...:||||:.|.::..:.|
  Fly    41 DRLVVQTSSGPVRGRSV-TVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATC 104

  Fly    73 LQ-----------VSTLTKEVEGSEDCLYLNISVKTL---------------------------N 99
            :|           ..........||||||:|:.....                           |
  Fly   105 VQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHN 169

  Fly   100 GDP------MPVMVYIHGGAFKGGDSSRRAWGPDYFMK-ENVVYISIGHRLGPLGFLSLNDPDL- 156
            |:|      :|::::|:||.|..|.::...:..|.... .||:..|..:|:|..|||.| .|::
  Fly   170 GNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHL-APEMP 233

  Fly   157 -----EVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRA 216
                 |.|||.||.|..||:||::.||..|.|:||.:|:||.|:||.:|...|.||.:.||..|.
  Fly   234 SEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRG 298

  Fly   217 ILLAGFSMELNR-LPQMEYRLAKHLGYEGDNVDSQVLEFLLKADPALIV----SADFFTPLEKRQ 276
            ::.:|   .:|. ...|....|..:|....| |......:||.:||.::    |.|..| :..:|
  Fly   299 MMQSG---TMNAPWSHMTSEKAVEIGKALIN-DCNCNASMLKTNPAHVMSCMRSVDAKT-ISVQQ 358

  Fly   277 GH------NMPFKPSIESYSTPNAVLLAEPIDLQRTTWSNRIPIILGANSGEG--MSIFSFVK-- 331
            .:      :.|..|:|:     .|.|.|:|:.|.:|.......|::|....||  ..::.|:.
  Fly   359 WNSYSGILSFPSAPTID-----GAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLLYDFIDYF 418

  Fly   332 ----------------MNPSWLKEFQCNPERVL----PWTLRNRCDPG--QRRQLGQALIHHFCE 374
                            ||..:.|..|...|.::    .|    ..:||  .::|:|:|:..||
  Fly   419 DKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSW----EGNPGYQNQQQIGRAVGDHF-- 477

  Fly   375 AHGHELTVDHTNGLVELFTHGFVHAMDRLIQSRLTYGQAPTYLYRFDFDSPDFNFYRIRFMGKEQ 439
                                 |....:...|:....|.:..|.|        |.......:..|.
  Fly   478 ---------------------FTCPTNEYAQALAERGASVHYYY--------FTHRTSTSLWGEW 513

  Fly   440 RGVGHVDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQFAATSDP 486
            .||.|.||:.|.|..|....|.....|....:|:::..::||.|.:|
  Fly   514 MGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNP 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	148/567 (26%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	47/121 (39%)
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	148/567 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440451
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840