DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and CG4757

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	166/546 - (30%)
Similarity:	234/546 - (42%)	Gaps:	85/546 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWH-GIRDCSKPLSKCLQV 75
            |.|..|:|||..|.|.....|:||.||.||.||||.|||..|..:|||. .|.|.|:....|.|.
  Fly    23 VDTELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDASEDGPMCPQP 87

  Fly    76 STLTKEVEGSEDCLYLNISVKTLNGDPMPVMVYIHGGAFK--GGDSSRRAWGPDYFMKENVVYIS 138
            .....:|  |||||.||:..|.|.| ..||:|::|.|.|.  .|.|...| ||::||..:.|.:|
  Fly    88 WDNMTDV--SEDCLRLNVYTKDLKG-RRPVIVFLHPGGFYVFSGQSKYLA-GPEHFMDRDCVLVS 148

  Fly   139 IGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQLL 203
            :.:|||.||||:....  |.||||||||.:||||||:.:...|.|||:.:|:.|:|:||::|.|.
  Fly   149 LNYRLGSLGFLATGSK--EAPGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALH 211

  Fly   204 LASPQSEGLFHRAILLAGFSMELNRLPQMEYRLAKHLGYEGDNVDSQVLEFLLKADPALIVSADF 268
            :.||.|.|||||.|.::.......:....:.:|||...            .|||.
  Fly   212 MLSPMSRGLFHRGICMSAAPYGPVKYKDNDLQLAKRQA------------GLLKC---------- 254

  Fly   269 FTPLEK--RQGHNMPFKPSIESYSTPNAV------------------------LLAEPIDLQRTT 307
              |.|.  .....|..||.::..||.|.:                        |:..|....|..
  Fly   255 --PQESIGEMVECMRRKPYLDYVSTYNGMFEFGWNPVLNWRIVVEKDFGQERYLIESPFKTARRG 317

  Fly   308 WSNRIPIILGANSGEGMSIFSFVKMNPSWLKEFQCNPERVLPWTLRNRCDPGQRRQLGQALIHHF 372
            ..:::.:|.|....|.:|...|...|.|.:..:..:.|......|....:..|.|...:.....:
  Fly   318 DFHKVALITGITEFEFLSGAFFDLRNESIVNRYNRDWEHYASIALLLEQNSTQSRAASRVFREKY 382

  Fly   373 CEAHGHELTVDHT-NGLVELFTHGFVH-AMDRLIQSRLTYGQAPTYLYRFD-----FDSPDFNFY 430
            ......:|....: .|:.||.:...:. :..|.:|....:....|||:|:.     ..:||
  Fly   383 MPESLDKLEYPKSLKGMGELLSDALIGVSFHRFLQLMSPHTPIYTYLFRYKGRYTFLKNPD---- 443

  Fly   431 RIRFMGKEQRGVG--HVDELGYIFKLPATFKLDKSR-PEFTAIRRLVAMFVQFAATSDP---NAP 489
                   .|:.:|  |.|||.|:|.:.....|.|.. ||...|..|..|:::||...||   |..
  Fly   444 -------NQQTIGPVHHDELIYLFHVGLLIPLLKREDPENFMIELLTRMWIEFAQKGDPHNKNDE 501

  Fly   490 LTKSLVDWKPVTRFGKRMVLNISEEL 515
            ..|.| :| |:.....:..|.|...|
  Fly   502 YLKGL-NW-PLYNAQDKGYLEIGNNL 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	166/546 (30%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	57/116 (49%)
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	166/546 (30%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	78/169 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467413
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.800