DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and Nlg1

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster

Alignment Length:	577	Identity:	145/577 - (25%)
Similarity:	223/577 - (38%)	Gaps:	159/577 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VQTTHGKVRGILLKSLYD---EQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIR---------- 63
            :|...|::.||..:....   .|...|.|:|||..|.|..||..|....||.|::
  Fly   158 IQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCP 222

  Fly    64 ----DCS------------KPLSKCLQVSTLTKEVEGSEDCLYLNISVKTLNGDPMP----VMVY 108
                |.|            |.||:.|..  |..|   ||||||||:.|........|    |:||
  Fly   223 QKLPDLSPHGSENMSRARHKHLSRLLPY--LRTE---SEDCLYLNLYVPHEEPQSTPKQYAVLVY 282

  Fly   109 IHGGAFKGGD------SSRRAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVP--GNAGLK 165
            :||.:|:...      |...::|       .|:.:::.:|||.||||.   |.::..  .|..|.
  Fly   283 LHGESFEWNSGNPYDGSVLSSYG-------EVIVVTVNYRLGVLGFLR---PSIDAHNIANYALL 337

  Fly   166 DVILALRWIRANAANFNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSME----L 226
            |.|.||.||:.|...|.||..|:|:.|||:|:..|..|:.||.:.||||||||::|.:|.    .
  Fly   338 DQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWAAS 402

  Fly   227 NRLPQMEYRLA--------KHLGYEGDNVDSQVL-----EFLLKADPALIVSADFFTPLEKRQGH 278
            |:..|:..::|        :|:..|.|:|....|     :.:|....||...:....|:.  .||
  Fly   403 NQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALTQFSTSLGPIV--DGH 465

  Fly   279 ---NMPFK------------------PSIESYSTPNAVLLAEPIDLQRTTWSNRIPIILGANSGE 322
               |.|:|                  ...|||.|..|:.|.|                 |....|
  Fly   466 VIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAALALEE-----------------GLRENE 513

  Fly   323 GMSIFSFVKMNPSWLKEFQCNPERVLPWTLRNRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNG 387
            ..::..|...:     .|...|:..|..||:..          |.:.::..:|    ..::|.:.
  Fly   514 RDNLLRFYMQS-----RFDIRPDLALAATLKKY----------QDMYNNPIKA----TNLEHRDV 559

  Fly   388 LVELFTHGFVHAMDRLIQSRLTYGQA--PTYLYRFDFDSPDFNFYRI--RFMGKEQRGVGHVDEL 448
            ::::.:...|  :..|:|:.:.:...  ..|:|.|..:|....|..:  ..||         :||
  Fly   560 VLDILSDARV--VGPLLQTGMFHADVNRRNYMYVFGHNSATGPFAHLPHSIMG---------EEL 613

  Fly   449 GYIFKLPATFKLDKSRPEFTAIRRL-----VAMFVQFAATSDPNAPLTKSLVDWKPV 500
            .:||..|...........:|...:|     :|.:..|..|.:|.||       ||.:
  Fly   614 AFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMAYWTNFVKTGNPKAP-------WKGI 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	145/577 (25%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	47/126 (37%)
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	145/577 (25%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	52/154 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.810