DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and alpha-Est3

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001163540.1	Gene:	alpha-Est3 / 40907	FlyBaseID:	FBgn0015571	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	209/553 - (37%)
Similarity:	310/553 - (56%)	Gaps:	42/553 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCLQVS 76
            |.||.|.|.|.....:|.:::.:|:.||||.||:|.|||..|..::||....||:||..|.||.:
  Fly     6 VNTTSGPVLGKQCTGVYGDEYVSFERIPYAQPPVGHLRFMAPLPVEPWSQPLDCTKPGQKPLQFN 70

  Fly    77 TLTKEVEGSEDCLYLNISVKTLNGD-PMPVMVYIHGGAFKGGDSSRRAWGPDYFMKENVVYISIG 140
            ..:|::||.|||||||:..|.|:.. |:|::|:..||.|:.||.::....|||||..:||.:::.
  Fly    71 HYSKQLEGVEDCLYLNVYAKELDSPRPLPLIVFFFGGGFEKGDPTKELHSPDYFMMRDVVVVTVS 135

  Fly   141 HRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQLLLA 205
            :|:|||||||||||.:.|||||||||.:||:.||:.||..|||||:.:|.||.|:|:.:|..|:.
  Fly   136 YRVGPLGFLSLNDPAVGVPGNAGLKDQLLAMEWIKENAERFNGDPKNVTAFGESAGAASVHYLML 200

  Fly   206 SPQSEGLFHRAILLAG---FSMELNRLPQMEYRLAKHLGYEGDN--VDSQVLEFLLKADPALIVS 265
            :|::|||||:|||.:|   .|..|..:..:.:|||.:||.|...  .|:.||:||.|.....:|.
  Fly   201 NPKAEGLFHKAILQSGNVLCSWALCTIKNLPHRLAVNLGMESAEHVTDAMVLDFLQKLPGEKLVR 265

  Fly   266 ADFFTPLEKRQGHNMPFKPSIESYSTPNAVLLAEPIDLQRTTWSNRIPIILGANSGEGMSIFSFV 330
            ....:..|........|.|.:|.|.|.:..|...|.:|....|.||||:::...|.||:.:::.|
  Fly   266 PYLLSAEEHLDDCVFQFGPMVEPYKTEHCALPNHPQELLDKAWGNRIPVLMSGTSFEGLLMYARV 330

  Fly   331 KMNPSWLKEFQCNPERVLPWTLRNRCDPGQRRQLGQAL-----------------IHHFCEAHGH 378
            :|.|..|...:..||.:||..::........|.|||.|                 :..:||...:
  Fly   331 QMAPYLLTSLKKEPEHMLPLDVKRNLPQALARHLGQRLQETHFGGNDPSAMSPESLKAYCEYASY 395

  Fly   379 ELTVDHTNGLVELFTHGFVHAMDRLIQSRLTYGQAPTYLYRFDFDSPDFNFYRIRFMGKEQRGVG 443
            ::               |.|.:.:.::||:....|.|||||||||||.||..|:::.|.:.|||.
  Fly   396 KV---------------FWHPILKTLRSRVKSSSASTYLYRFDFDSPTFNHQRLKYCGDKLRGVA 445

  Fly   444 HVDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTKSLV----DWKPVTRFG 504
            |||:..|::....::||||..|||..|.|::.|...||.||:||..|.:..:    :|||:....
  Fly   446 HVDDHSYLWYGDFSWKLDKHTPEFLTIERMIDMLTSFARTSNPNCKLIQDQLPRAKEWKPLNSKS 510

  Fly   505 KRMVLNISEELKFIPQPEMPKLKFFDRLYEMAG 537
            ....|||||.:|.:..||:.||:.::.:.:..|
  Fly   511 ALECLNISENIKMMELPELQKLRVWESVCQSTG 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	208/543 (38%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	61/114 (54%)
alpha-Est3	NP_001163540.1	Abhydrolase	3..529	CDD:304388	205/537 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467383
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.890