DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and alpha-Est6

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	208/537 - (38%)
Similarity:	306/537 - (56%)	Gaps:	22/537 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DAPVVQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKC 72
            |:.||:.:.|.|:|..|..:|.::||:|:|||:|.||||..||.......||:...|..:.....
  Fly    39 DSKVVKLSVGSVKGRRLSGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPWNSELDARQERPIP 103

  Fly    73 LQVSTLTKEVEGSEDCLYLNISVKTLNGD--PMPVMVYIHGGAFKGGDSSRRAWGPDYFMKENVV 135
            ||:...:.:|.|||||||||:..|..|..  |:||||||:||||:.|.:.:..:||||.|..:||
  Fly   104 LQMDRRSGKVVGSEDCLYLNVYTKHFNESEPPLPVMVYIYGGAFRTGGAVKSKYGPDYLMSRDVV 168

  Fly   136 YISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTV 200
            |:...:||..|||||:....|:|||||||.|.:|||:|:..:..||||||:.||:||.|:|:.:|
  Fly   169 YVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASV 233

  Fly   201 QLLLASPQSEGLFHRAILLAG--FSMELNRLPQME---YRLAKHLGYEGDNVDSQVLEFLLKADP 260
            ..::..||::||||:||:::|  .|..:| .|..:   .|||...||||...:..:||||...:.
  Fly   234 HFMMCLPQAKGLFHKAIMMSGSMLSPWVN-APDSDGIFCRLATSAGYEGPAEEVPILEFLRNVNA 297

  Fly   261 ALIVSADFFTPLEKRQGHNMPFKPSIESYSTPNAVLLAEPI-DLQRTTWSNRIPIILGANSGEGM 324
            ..::..||.:|.::..|...||.|.:..       |:|.|. .|.:..||..:|::||..|.||:
  Fly   298 EKLIGHDFISPRDRCFGFLNPFAPVVGG-------LVAAPFQQLMKEAWSCEVPLLLGGTSFEGL 355

  Fly   325 SIFSFVKMNPSWLKE-FQCNPERVLPWTLRNRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNGL 388
            ..:.|.:::..::.| .:..|..|||..|.......:|......|:.:.....|  :|..:...:
  Fly   356 VYYPFCQLDNGYMLELLKHEPAMVLPHELYQSMSVEERNTAADVLVKYHYGPRG--ITKSNITQI 418

  Fly   389 VELFTHG-FVHAMDRLIQSRLTYGQAPTYLYRFDFDSPDFNFYRIRFMGKE-QRGVGHVDELGYI 451
            ::||::. |.|.:.|::.|||::.||||||||||||||..|..|.:..|.: :|||.|.|:||||
  Fly   419 LDLFSYKLFWHGIHRVVLSRLSHAQAPTYLYRFDFDSPKLNLMRNQLCGDDIKRGVCHADDLGYI 483

  Fly   452 FKLPATFKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTKSLVDWKPVTRFGKRMVLNISEELK 516
            |...|..|.....|||..|:|:|.:...||.|.|||.|.| ....|.||:.......|||.::::
  Fly   484 FHKQAQAKQPLDSPEFLTIQRMVGILTTFARTGDPNCPET-GPDPWMPVSTKSPFKALNIGQQVE 547

  Fly   517 FIPQPEMPKLKFFDRLY 533
            .:.|.|...||.::|||
  Fly   548 CVTQVEKDGLKVWNRLY 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	205/531 (39%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	60/114 (53%)
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	198/505 (39%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	83/192 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467386
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	10	9.900