DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and alpha-Est7

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	226/558 - (40%)
Similarity:	322/558 - (57%)	Gaps:	60/558 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VVQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCLQV 75
            |..|.:|:||||...||||..:::|:|||||.||:|.||||.|....||..:||||:|..|.:||
  Fly    34 VADTEYGQVRGIKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRDCSQPKDKAVQV 98

  Fly    76 STLTKEVEGSEDCLYLNISVKTLNGD-PMPVMVYIHGGAFKGGDSSRRAWGPDYFMKENVVYISI 139
            ..:..:|||||||||||:....:..| ..||||:||||.|..|:::|..:||||||||:||.::|
  Fly    99 QFVFDKVEGSEDCLYLNVYTNNVKPDKARPVMVWIHGGGFIIGEANREWYGPDYFMKEDVVLVTI 163

  Fly   140 GHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQLLL 204
            .:|||.|||:||..|:|.|||||||||.:|||:||:.|.|:|.|||..||:||.|:|..:...::
  Fly   164 QYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGESAGGASTHYMM 228

  Fly   205 ASPQSEGLFHRAILLAG-------FSMELNRLPQMEYRLAKHLGYEGDNVDSQVLEFL--LKADP 260
            .:.|::|||||.||.:|       ::.::...|   ||:||.:||:|::.|..|||||  :||..
  Fly   229 LTDQTQGLFHRGILQSGSAICPWAYNGDITHNP---YRIAKLVGYKGEDNDKDVLEFLQNVKAKD 290

  Fly   261 ALIVSADFFTPLEKRQGHNM-PFKPSIESYSTPNAVLLAEPIDLQRTTWSNRIPIILGANSGEGM 324
            .:.|..:..| ||:|....| .|.||:|.:|||..|:...|.::.:|.|||.||:.:|..|.||:
  Fly   291 LIRVEENVLT-LEERMNKIMFAFGPSLEPFSTPECVISKPPKEMMKTAWSNSIPMFIGNTSYEGL 354

  Fly   325 SIFSFVKMNPSWLKEFQC--------------NPERVLPWTLRNRCDPGQRRQLGQALIHHFCEA 375
            .....||:.|..|::...              :.|::..|:.:.|                  :.
  Fly   355 LWVPEVKLMPQVLQQLDAGTPFIPKELLATEPSKEKLDSWSAQIR------------------DV 401

  Fly   376 H--GHELTVDHTNGLVELFTHGFVHAMDRLIQSRLTYGQ-APTYLYRFDFDSPDFNF-YRIRFMG 436
            |  |.|.|.|:...|..::.  ||....|::.||..|.. ||.|.||:||||.:..| |||..:|
  Fly   402 HRTGSESTPDNYMDLCSIYY--FVFPALRVVHSRHAYAAGAPVYFYRYDFDSEELIFPYRIMRLG 464

  Fly   437 KEQRGVGHVDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTKSL----VDW 497
            :..:||.|.|:|.|.|......:|.|...|:..|.|.|.::.|||||.:|.:.....:    :|
  Fly   465 RGVKGVSHADDLSYQFSSLLARRLPKESREYRNIERTVGIWTQFAATGNPYSEKINGMDTLTID- 528

  Fly   498 KPVTRFGKRM-VLNISEELKFIPQPEMPKLKFFDRLYE 534
             ||.:..:.: .||||::||||..||.||||.::.||:
  Fly   529 -PVRKSDEVIKCLNISDDLKFIDLPEWPKLKVWESLYD 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	224/551 (41%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	65/114 (57%)
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	206/503 (41%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	58/104 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467384
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	10	9.900